Genomic Feature
mg3
- ID
- ZDB-ALT-240613-6
- Name
- mg3
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Armstrong Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 15: 5777467 - 5777473 (GRCz11) (1) Details
- Nucleotide change
- AGCAGTG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AATGAATGAATGAATGTTTGCTTATTTATTTGCTGCTAATGTTAACTATTTTTTCCTTTTGTATATAATAATATTAAACATATTACTGACCATTTAACTGTTTATTTACAATGAAACACCTCCAGGAGAACATATTTAGTAATTTGGGAATTCTTTTTGCGGGGGATCCCTTATTATGGTGGGAAATTTCCTTATTTTCACATCCCAATGTTGACAGGTATGCGAGTACTCTATTGTCAGTAGTCATTACCTATTGAGGTTAAAGTTATTTTGTCCAAAATAAAAATTTTATGTCATTCTAATGCTCTGAGACCTTCATTCATCTTCAGAACACTTTTTATAAAATAAAAATAAATGTAAAATGAATGCACCCGTGCCATAACGTTTACCTGATAGGTCACATCGGGCCTAGCAGCTTCAGAATGTCCCCCTCCGCCAAAGCCACCGGTCATGGCGTGACCTATTGTGTGTCCGACAGCAGAGCCGACAGCAACGCCTGC
AGCAGTG/- GAGGCCATCTGAGCGAACATTCCCGGCTGACGGGGAGCAGCAGCAGCAGGAGGAGCCACCGCTGAAGGTGGAGGAGGAGCCGGAGCGGGTGCGTAAGACCGCGGAGGAGCTGCTCGAGCCATCGGTGCTGGTGAGGAGTAACTAAAAAGAAAACTGCACAATCAATTACCTGTCCTTTGACAATGACTTGGAGTAGGGTTGCACGATACTGGGGAAATGTGCCATATTGCTGTTGAGCATTGTGACAGCGATATTTCTTGTGATATAAAAACCTTCCTAGAGAAATGCTATTTTATTAACCCTTTTTTAATATAAATTTATGTAATGATATACACTCACTGGCCACTATATTAGGTACACCTGTCCAACTGCTTGTTATGCAAATTTCCAATCAGCCAATCACATGGCAGCAACTCAATGCATTTAGACATGTAGACACGGTCATGACGATCTGCTTCAGATCAAACCGAGTTTGTTGTTGTTGGTCCCAGATGGGCTGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| chchd2mg3/mg3 (TL) | Homozygous | ♀+/- ♂+/- | 3 figures  from Légaré et al., 2024 | Fig. 5 from Légaré et al., 2024 |
1 - 1 of 1
Show
Supplemental Information
- Genotyping protocol
- None
- Légaré, V.P., Harji, Z.A., Rampal, C.J., Antonicka, H., Gurberg, T.J.N., Persia, O., Rodríguez, E.C., Shoubridge, E.A., Armstrong, G.A.B. (2024) CHCHD10P80L knock-in zebrafish display a mild ALS-like phenotype. Experimental neurology. 382:114945
- Légaré, V.P., Rampal, C.J., Gurberg, T.J.N., Aaltonen, M.J., Janer, A., Zinman, L., Shoubridge, E.A., Armstrong, G.A.B. (2023) Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response. Developmental Neurobiology. 83(1-2):54-69
1 - 2 of 2
Show