Genomic Feature
co66
- ID
- ZDB-ALT-240220-1
- Name
- co66
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Nichols Lab
- Current Source
- Other Pages
-
Notes
| Comment | Citation |
|---|---|
| Mutation is homozygous lethal, there are no survivors at 12 dpf. | Stenzel et al., 2022 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 23400262 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T in Exon 4 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Gln>Stop at position 149 (1)
- Flanking Sequence
-
CCTTAGAACGGAACTGAACGTATATTCTTCACCATGAAAACTTTATAAGTTCATATGAGATGCGCAAGTCTACCAGGGTCTCCACACCGGCTCATTGCTTTCTGCTCCGGCACTGACACCAACGGGACTGACGGCTTGTGGAACGCCCGAGAAGGAGGTCATTCCCTGGACAGGAGATGCGACCGTGGGAGCCGAGCTGGCCTGGACGGGACTGGCGTTGACAGTTACTGGAACGCTTGCGTTTGCGTACAAGGGAATGACTGGAGTTGTAGCAGAAGCAAACGCTGGGTTGGGGATAAGAAAAGCAAACTGTCCGTCCGTGGCTGGCACCAGCTGGAATCCTCCAAAGACTTTTGGTGAGACCGCTTCTGAAGGACTGAGTTTGGAACCCATTGAGGCGCCGTTGATGGGTAACGTTGAAGGAAGCTGCACGTGAAGAGGCTGAGCCAAATGAGCCTGTTGAGCGGGGGCAGGCTGAGGGTAGTTCATGGCCATCATCT
G/A TCCCATACAACCGGACAGGTGGTTAAGAAGTCGCGATCTGACCTCTGTATTCACTCCCTCGCAGGTAGAGAGAAATCGAGTCACCTCGTTCATGCACTCGTTGAATCCTGCGCGGTACTTGCTGAGGACGTTTGTGTCAGCTGACAAGGCTGCTGGTAAACAAAGATAAAACGTATTTAGATTGTGTATTCAGGAAATTAAATTGCGTTTTTAAAAGCACGTTAAAAGTTTATCATCTTGAGGAATCTGACTTGCAACTTACCGCTCATCTGAACACGTTGTAAATTGCGCAGGTGCTTGACTGTCATCTCCAGAATATCAGCTTTCTCCAATTTAGAGTGTCTGGAGCTCTGTGAATGAGCAGAATTCGGTTAGAAACTGTTTCAGAATTACTAACGTCGGGTGACTGAAGCATGACAAGAGTTGTAGATAAAACTTACATCTTTTTTAAGAGCATCAAGAATGAGAGTCTTCAGCTGCCCAAGGCTCTCGTTGATTCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| her9co66/co66 | Homozygous | ♀+/- ♂+/- | 3 figures  from Stenzel et al., 2022 | ||
| her9co66/+ (AB) | Heterozygous | Unknown | |||
| her9co66/co66; b1212Tg/b1212Tg | Complex | 2 figures from Stenzel et al., 2022 | |||
| her9co66/co66; her6co3005/co3005 | Complex | Figure 8 from Stenzel et al., 2022 | |||
| her9co66/co66; jag1bb1105/b1105 | Complex | Figure 7 from Stenzel et al., 2022 | |||
| her9co66/co66; jag1bb1105/+ | Complex | Figure 7 from Stenzel et al., 2022 | |||
| her9co66/+; jag1bb1105/b1105 | Complex | Figure 7 from Stenzel et al., 2022 | |||
| her9co66/co66; jag1bb1105/b1105; her6co3005/co3005 | Complex | Figure S6 from Stenzel et al., 2022 | |||
| her9co66/+; jag1bb1105/b1105; her6co3005/co3005 | Complex | Figure 9 from Stenzel et al., 2022 | Figure 9 from Stenzel et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Stenzel, A., Mumme-Monheit, A., Sucharov, J., Walker, M., Mitchell, J.M., Appel, B., Nichols, J.T. (2022) Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Frontiers in endocrinology. 13:10338431033843
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