Genomic Feature
zf3610
- ID
- ZDB-ALT-230807-1
- Name
- zf3610
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with CRISPR
- Lab of Origin
- Jun Zhu Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 13: 49444177 - 49444181 (GRCz11) (1) Details
- Nucleotide change
- CGACG/-
- Variant Notes
-
The mutation is expected to produce a truncated 122 amino acid protein.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GATGCAGGACCAGTCTCGTACATGACCCTCTGCTGCATGTGCTCCTTCTTGAATCTGCCGTCGTACGGGTTGAGCGTCATCAGCTCCCGCACGGTTTTGTTCTTGTTGAGCCAGTCGTCGGCGCGCGTCTTGTGGCCGTCGCTGATCTCCGGCGTCAGGCTGTCCGGTCTGTGCTTGTCCTTGTCGTGCTCTGTGCTGGAGACCGACGCCGGTCGCTTATTCCCTCCGAGATCTGACATCTGCCCCGGTCTGCCGTTCATCGCGTGCGCCATGCTGCCGTTCACTAAAGGCACTAAATTGGGCGGCACGCCGCTAGTCCTGCGCGGGTTCGGGCTCTGGCGGTTGAGCTCCGGAGGATCGTCGGGTTTTGAGAATCCGTTAGGCACTGGGATGCCGTTCGCCTGTCTCGCAGACTGATACTCGGCTCCCAATCTGGGCGGACGCTCTGAGGAGAGCGGGTAGCGATCCAGCGGCTGCGGCGGGCGCGAGCCCGGGTCTCC
CGACG/- CGTGGATCTCCTTCCCCGGTAACTGTTTCCCCGGCCCCGCCGGTCTGCCGTCCTGAAATCCATGCGCTCTTTTGAGCTGCCGGGCTGTTTCAATGACAAACTCGATCCTGTCGGCTCCTTCGTAGTTGACACATCCTCTGCAAACGGGCTCGGTAAAATCCCAGATCATAGCCCACGGCATGCGGGGCAAGTCACATAAATAACACGACTGCCTCCTCGAAGCAGCAACCGCCGCGGACGACATCGCTCTCTCTCGGGCGAAAACCCCTCCGAAATACGGCACAATCCTGTGTGGAATGATGCTGGGGAAAAACAAGGTAGGTTCCTGTCGCGGTGGCGCAAGTAATAATTAAGTTACAAACAGAACTTCATAGTAGCGTGCTTTACTACGACGCGCGCTCGGTCTCTCTCACTCACTACTACCGCGGCCAGGCTGGAGCTCAATGTGGAGCAGTGACGTCACCGCCGCTCCGCGTCTATTTACTTGATTCTTCGACAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| irf2bp2azf3610/zf3610 | Homozygous | Unknown | 5 figures  from 2 publications | 4 figures from 2 publications | |
| irf2bp2azf3610/zf3610; rj30Tg/rj30Tg | Complex | Fig 2 from Gao et al., 2021 | Fig 2 from Gao et al., 2021 | ||
| irf2bp2azf3610/zf3610 + MO1-gfi1aa | Complex | Fig 4 from Gao et al., 2021 | Fig 4 from Gao et al., 2021 | ||
| irf2bp2azf3610/zf3610 + MO7-tp53 | Complex | Fig. 3 from Yan et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Yan, L., Gao, S., Zhu, J., Zhou, J. (2022) Irf2bp2a regulates liver development via stabilizing P53 protein in zebrafish. Biochimica et biophysica acta. General subjects. 1866(10):130186
- Gao, S., Wang, Z., Wang, L., Wang, H., Yuan, H., Liu, X., Chen, S., Chen, Z., de Thé, H., Zhang, W., Zhang, Y., Zhu, J., Zhou, J. (2021) Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish. PLoS Genetics. 17:e1009693
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