Genomic Feature
zf3406
- ID
- ZDB-ALT-220307-17
- Name
- zf3406
- Synonyms
-
- cwr2 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- McDermott Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 25636191 - 25636195 (GRCz11) (1) Details
- Nucleotide change
- TCCTC/-
- Variant Notes
-
?5 bp at c.799?703 (?GAGGA)
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted in Exon 7 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGGTGGTGGAGGCAAACTTGTTGTCGGCTGTCTCTGGGTTTCCTATAAGGTAATCCCAGCTAGTGAACAGCTTCCAGCAAAAGGTGAAGTTACCTTCATCTCCTCCATCTCCTCCTTCATTGGCGTTTCTGGCCATTCTAAAATATGCAGATGATTAGGAAGTAAATTCTGCACTCTCAGCAAGTAAAGTAAACCCCCTTGCAAGTTTACATAAAGCTCTGATCAGAAAACTCACGTTCTGATAACCACCATTAGACTATAGCCAAATATCCCAACACCAACCAGAAGGTATGACAGAGGTAACCGGAACTGCAGGAATCCAATAGTTCGTTGGTTGTTGTAGAAACCATAAAACAGAATGGAGTACTTGCAATAACCCTGTAAAAAATGTCAAAGGTATAATGAGGGGAAACTTACAGCTTGTTATACAAAGAATCTGCTAGTAAAAAACTCTTACTCCAAACTCAAATAGCACAGAGAAGTCCATGGCCGAATCCTGC
TCCTC/- TCTGGGGACTGTTTTTCTGGGAATAGAGCCATAAGGGATGCCCATTAATAACTACAAAGAAAACAACACAGATTGGGTTAACATTACAATACACATAATGCACACAACACAACATACATTCCCATTCTCTATAAACAAATATTTTGATAACAGTATCACATCTCACCTCTGGAATAACAACAAGTCCAAACATGAAGCCGAAGAGAACAAGGTTTAGTCCATACATCCATCTCAAGAAAATAAAATAGGAGGCAACAGATGATCCAAAATGGCCTACAAGAAACAGATGACACTGATGAGAAAATAATATAAAATACAGAAACATCAGGGGGGAAACACAGAGATGAACAGACTTTCTACTTCTTTTATTCGACTCTCCCAGGGAATGCAAGCCGTCTTGAAGTTTTCAAAGTCTCTATTGAATTTGATTAATTTCTGAGAAGCAAAGACAACACAAATGTTCAGTTATTGCCGTTAGGAAGAAACTTAAACAGTGAACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tmc2azf3403/zf3403; tmc2bzf3406/zf3406 | Complex | FIGURE 2  from Zhu et al., 2021 | |||
| tmc2azf3403/zf3403; tmc2bzf3406/zf3406; idc1Tg | Complex | FIGURE 2 from Zhu et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Zhu, S., Chen, Z., Wang, H., McDermott, B.M. (2021) Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear. Frontiers in cell and developmental biology. 8:570486
- Chen, Z., Zhu, S., Kindig, K., Wang, S., Chou, S.W., Davis, R.W., Dercoli, M.R., Weaver, H., Stepanyan, R., McDermott, B.M. (2020) Tmc proteins are essential for zebrafish hearing where Tmc1 is not obligatory. Human molecular genetics. 29(12):2004-2021
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