ZFIN ID: ZDB-GENE-060526-262
Gene Name: transmembrane channel-like 2b
Gene Symbol: tmc2b    Nomenclature History

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Previous Name: si:dkey-229d2.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have mechanosensitive ion channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound; inner ear morphogenesis; and neuromast development. Predicted to localize to integral component of plasma membrane. Is expressed in inner ear; neuromast; and neuromast hair cell. Orthologous to human TMC2 (transmembrane channel like 2).
Genome Resources: Alliance (1),  Gene:567304 (1), 
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cwr8 Small Deletion Exon 4 Premature Stop TALEN
cwr9 Small Deletion Exon 7 Unknown CRISPR
sa8817 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38469 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tmc2b 1
    TALEN1-tmc2b 1
    DISEASE ASSOCIATED WITH tmc2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tmc2b VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tmc2b-202 (1)    Ensembl 2359
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tmc2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myo6b:tmc2b-EGFP) myo6b EGFPtmc2b Danio rerio 1 2
    MARKER RELATIONSHIPS
    tmc2b Contained in: [BAC] DKEY-229D2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001302223 (1)
    Genomic GenBank:BX296526 (1) 179086 nt
    Select Tool
    Polypeptide UniProtKB:A0A5H1ZRH4 (1) 892 aa
    Sequence Information (all 11)
    ORTHOLOGY for tmc2b ( Chr: 5 )
    CITATIONS (19)