Genomic Feature
fb401
- ID
- ZDB-ALT-211104-3
- Name
- fb401
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Eric Liao Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 16: 26674594 - 26674597 (GRCz11) (1) Details
- Nucleotide change
- CACA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 3 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CCAAACAGTAGTAGTCAAAAAACTAATAAATGGGAGTCAATGGCTACAGTTACTCTGTTTATCAACAACATTCTTCCACATATGTTTTGTCCTCAGAAGAAAGCGATTTATACATGTTTTGAACAAGTGATGGATGAGTAAACATGTAATACACAATTTCTAAAAATACACTATACAATGGTATTTGCCTTTTAAACAACATAAAAAAAGGATACGGTCAGCCATGACCTGAAGATTCAAGTCTTTCAGCTTCACTTCTGATGGGAATTCTTTCTTAAACTCTTTCCGCAGGTCGAAGAACGAGAAGAAACAATCCGGCAACAAAATATTCTGAAAAATATGAAAGAAAGCTGTCATGAACGAACACACATCTGCACTAGCTAAACTTTCACACAATGCATTAGTCACAAATATCATATTGCCTGCAATATTTGGAGATTGTCACCTTGCTGGAAGCCTCGGGATGCAAGACTTGACGCACGTGAAGCTGTCCATCCGTA
CACA/- GGTAGAAGGTGTTTCCTGCACCTGTGTCCACTTCAGCACACAACCTCTGATTCAACTGCACACACAAAGACGCTATTTGAGTAAACGCCACTTTTATGTGGCATTTAATGCATACCCATGAAGCTCCTTGTGCAAACATCAGTCCACAAGCTGTTAAATAATATGCTTAATAGTCAGTAAAGATGTGCATTGGAGTTTAAATGGGTATAGGCAGACCCTGCATCAATGGGAGATTGTATAGAAGCTTCTTTTGAAATGATTTACACTGAATGCAAACTTCCCAACACAACATGTCATATTCAATGTTGATTCATGAAGAACAGATTTTATGAGAATGATCACCTGATCAATGGCGACTTCGAGGGGATCTACAGGTGTCAAAGCCTCATCTGTGAGTCCGCTGAGCTCCTGACACTCTTCCGAGAGTTCAATGTGGTCCGGTTTGACTAGCAGTTCATTTACCTGACCGGCCTTAACCAATGGAGAAAGAAAAGGTATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| esrp1fb401/fb401 | Homozygous | Unknown | 2 figures  from Caetano da Silva et al., 2024 | ||
| esrp1fb401/fb401 (TU) | Homozygous | ♀-/- ♂-/- | Fig. 5. from Carroll et al., 2020 | ||
| esrp1fb401/fb401; esrp2fb402/fb402 | Complex | 3 figures from Caetano da Silva et al., 2024 | Fig. 1 from Caetano da Silva et al., 2024 | ||
| esrp1fb401/fb401; esrp2fb402/fb402 (TU) | Complex | 3 figures from Carroll et al., 2020 | 2 figures from Carroll et al., 2020 | ||
| esrp1fb401/fb401; esrp2fb402/fb402; zf393Tg (TU) | Complex | Fig. 6. from Carroll et al., 2020 | Fig. 6. from Carroll et al., 2020 | ||
| esrp1fb401/fb401 + MO1-esrp2 | Complex | 2 figures from Caetano da Silva et al., 2024 | |||
| esrp1fb401/fb401 + MO1-esrp2 (TU) | Complex | Fig. 5. from Carroll et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Caetano da Silva, C., Macias Trevino, C., Mitchell, J., Murali, H., Tsimbal, C., Dalessandro, E., Carroll, S.H., Kochhar, S., Curtis, S.W., Cheng, C.H.E., Wang, F., Kutschera, E., Carstens, R.P., Xing, Y., Wang, K., Leslie, E.J., Liao, E.C. (2024) Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Communications biology. 7:10401040
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
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