Genomic Feature
cmg105
- ID
- ZDB-ALT-211006-3
- Name
- cmg105
- Synonyms
-
- c.165del10 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Speleman Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 14: 31497545 - 31497554 (GRCz11) (1) Details
- Nucleotide change
- GACAGTGAAA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 10 bp deleted in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ATTGCGTGTGTTTTTTTAAAGTTTACTAAACAGTACAATATTTAAATTTGTCAACATCTTAGAAGCTTTTTAAAATGTATTATTCACAACAAATCAACAAAAAAGCCTTTCAATTTGTCGACTTTTAACAAACTGGTCTCAGGCAGTGGAAAAAAGAAATAGTACATTGTGTGTGATGTGATTAAAATGCAGTTTTGTCAATCTGATCACAAGTGGAAAATGCTGAAATATGGTTTTGAATAGGGGGAGCTCTCTATGAAATCAGGAAAACGGACAAAAGTGACTAGGTTTAAACAGAAGTGTATCTTCCTATCTATTTGTGATCTAATTTACCAGAGCAAATCTTAAATCCAGGTGCAAACTGGGCCAATAATGTTAATTGCATATACAAAGACATGAAACGTGCGATAACATTTATTGTATCTAACAAATGCCTTGTGTGTGGTTTGTTTTTGTTTTCAACTCAGCTATTCTCATCAGCCTTGGTCACATCTCATTCA
GACAGTGAAA/- ACATCGGAGGCTTTTCTATTGAAGATGTGAAGAAGGAGATAAAAAGAGGAAATAAACTAGTATGCATTCAGTCCAACACCTTTCAAAAAACGTAGTCCTTTATTTAGGCTAAAAATAGAGAATGACCTATAGCCTTTTTTTTCTGTTCAGATGTGCACTTCCTGTCACCGGCCTGGGGCGACCATCGGCTGTGATGTAAAAACATGTAGAAGGACGTACCATTACTATTGTGCTCTATGGGATAAAGCCCAGACCAAGGAGAATCCCTCTCAAGGCATCTATCTGTAAGCATCATGAAGACACCGCATGGTTAAAGGAATAGTTTACCTGACAATGACAATTCTGACATCATTTACTCACCCTTCACTTGTTTCAAACCCGTTTCTTCTGTTGAACACAAAAGAAGATATTTTGAAGAATGTTGAAAAGCAGTAGCCTTTGACTTCCATCTATATTTTTGTTTTACTATGCAAGTCAATGGTTACAGGTTTTTAACTTTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| phf6cmg105/+ | Heterozygous | Unknown | Fig. S4 from Loontiens et al., 2020 | ||
| phf6cmg105/+; cmg106Tg | Complex | Fig. 1 from Loontiens et al., 2020 | Fig. 2 from Loontiens et al., 2020 | ||
| phf6cmg105/+; zdf8Tg | Complex | Fig. 7  from Loontiens et al., 2020 | Fig. 7 from Loontiens et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Loontiens, S., Dolens, A.C., Strubbe, S., Van de Walle, I., Moore, F.E., Depestel, L., Vanhauwaert, S., Matthijssens, F., Langenau, D.M., Speleman, F., Van Vlierberghe, P., Durinck, K., Taghon, T. (2020) PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation. Frontiers in cell and developmental biology. 8:599472
- Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403
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