Genomic Feature
ug701
- ID
- ZDB-ALT-210820-2
- Name
- ug701
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Neerman-Arbez Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 1: 10070079 - 10070088 (GRCz11) (1) Details
- Nucleotide change
- CGTGCTCAAT/ACA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 3 bp inserted / 10 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CCTCCACCAGGAGACGTCGAATCTTCTCAATCTTCTTGAGGAGATCATGGTCAGCTTTGTCCATGAGGCCTTGAACTCGGCAGCCAGATGGACATTTGCTTCCCTATATTGAGGATTGAAAGAAACATTTACTGCAACAAATTTGTTGATAGAGATTTTTGTGTTTTGTCTAATTATTGAGTCAATATTTATGACTTATATAATATATAGTAATAGGTAGTATATGAAGACTTCTAAATGCCGTCTGAAATTTTTTATCCAGCCAACTCGAATGTTTTACACTCAATTGTATGGGCGTAATCAGTGGTTATCAGCTGACAGATATGGGCCAGTAGGGGTCCTCTGCGCATATAGGCTTAGAAGGCTGTTATCATTCATCCACATGATGGTGGATGGATGGAATGAACGAAGTGAAGAAAAACAGTGAGAAACCCATACCCAGTCATCATCGGTACACCCTGGCCATTCTTTTGTCTGGCAGGTGTCTTGTGCCTTGAAGC
CGTGCTCAAT/ACA AGGACGAGCGCCTCTAGGGTTCACCACTGTGTCCTCCTCGGCCTAAAAAGTAAGTACTTTATAACTACTTAGGTCTGCCAACATAGGCCATTTTAACATACAGTGCTCAGCAAATAAGTACACCCTTTTGAAAACTACTATTTTATCCATTTCTCAGTGAATGTAGTCAAGAAAATACATTTAAATTGAAACATGTCATTCCAACAAAATTTGATCTTTTTTATTATTCTATTGATTTTTAATATTAATTAAAATTTTATAATTTTTTTTTTTATTAATTTTACTATATTTTAACTAATTTTTAGACTTTGATCTCACGATTTTTTTGTCAGATTAGTTCCAGTTTTGGCTTAAATAAATACTAATCTAATGTATATGCACAAATATATTATTGTAGAGCATCCTATACACTGTAAAAAAAAATATACAGTTGAAGTCAGAATTATTAGCCCCCTTTGAATTTTATTTTCTTTTTAAATATTTCCTAAATGATGTTTAAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fgaug701/ug701 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | ||
| fgaug701/ug701 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 2 from Fish et al., 2014 | Fig. 1 from Fish et al., 2014 | |
| fgaug701/ug701 (TU) | Homozygous | ♀+/- ♂+/- | |||
| fgaug701/+ | Heterozygous | ♀+/- ♂+/- | 2 figures from 2 publications | ||
| fgaug701/+ (AB) | Heterozygous | ♀+/- ♂+/- | Fig. 1 from Fish et al., 2014 | ||
| fgaug701/+; la2Tg | Complex | Figure 2 from Fish et al., 2021 | Figure 2 from Fish et al., 2021 | ||
| fgaug701/ug701; la2Tg | Complex | 2 figures from 2 publications | 2 figures from 2 publications |
1 - 7 of 7
Show
Supplemental Information
- Genotyping protocol
- None
- Fish, R.J., Freire, C., Di Sanza, C., Neerman-Arbez, M. (2021) Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders. International Journal of Molecular Sciences. 22(2):
- Freire, C., Fish, R.J., Vilar, R., Di Sanza, C., Grzegorski, S.J., Richter, C.E., Shavit, J.A., Neerman-Arbez, M. (2020) A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis. Blood advances. 4:5480-5491
- Vilar, R., Lukowski, S.W., Garieri, M., Di Sanza, C., Neerman-Arbez, M., Fish, R.J. (2020) Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis. Thrombosis and haemostasis. 121(4):433-448
- Fish, R.J., Di Sanza, C., Neerman-Arbez, M. (2014) Targeted mutation of zebrafish fga models human congenital afibrinogenemia. Blood. 123:2278-81
1 - 4 of 4
Show