Genomic Feature
mw711
- ID
- ZDB-ALT-210524-1
- Name
- mw711
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Semina Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 2: 688591 - 688617 (GRCz11) (1) Details
- Nucleotide change
- GCTGCGG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CGGGACGGTGCTTAGCGTGGGCGAAACAGCCTGCGGAGGAGTGGACGTGCCGTTCTCGGTTTTAATGTCCTGAATGCGCACGGGCTGAGAGCCAGGCACCGACTGCTCCTGCTCGCGGGCCTGCGGCTGCGCCTGGCGGGACGGCGCCTCTTTAACACCTCGGTCCTCCTTGTCCTTCATGGCGTCCTTCTTTTTAAATCGCCGTCGTCGCCTCAAAAAGCTGCCGTTCTCAAACATATTATACGAGTCCGGGTCGAGGGTCCAGTAGCTGCCTTTTCCGGGTTTCTTATCATCGCGTGGAACTTTGACAAAGCACTCGTTCAGGGATAAATTATGCCGGATGCTGTTCTGCCAGCCCTGCTTGTTGTCTCTGTAAAAGGGAAAGCGCTCCATGATGAACTGATAAATACCATTAAGGGTCACCTTTTTGTCCGGGGAGTTCTGGATTGCCATTGTGATGAGCGCAATGTAGCTGTACGGGGGTTTCACCATATCCTTAG
GCTGCGG/- ATGCCCTCGCCATGCTGGCGGGGTACTGGTCGTGGGCCGCGTGAGAGTACATGGTCATGGGGGCTGGCATGCCGGTGTACCCCCCTCCGGCGGCGGCTCGGTAATAACTTTGGTCGCTGCTGATGTACGGCACAACTCCCAGCGAGTTGGGACTGGAGACGGAATAGCGCGCCTGCATGACTGCTCTCCAAAACGGCGTACAGCTGGCGAAGAACAGTCGTCAAGAAGACTGAAGCAATCCACACACAGACACACACACACACACACAATCCTGCTTGAAATGCGCCTCCTCTGAATCTGGGAATGGGAATCCACCACAGAGTCCACCGTATTTACAAAACCGGACTATTGCACCGGGTGTTGATAAGACTCGCGTACTGGCCACCTCTTTCTCTCGGAGCGCGCATCGGAAAACTTCTAAACGCTAAGCATCGGTCACTACATAATAGTTTTTGCGCACTTCAATACTTTTCCCCTTTTGCTGCCAGTAAGACTCCTCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| foxc1amw711/mw711 | Homozygous | ♀+/- ♂+/- | Fig. 1 from Ferre-Fernández et al., 2020 | ||
| foxc1amw711/+ | Heterozygous | ♀+/- ♂+/- | Fig. 4 from Ferre-Fernández et al., 2020 | ||
| foxc1amw711/mw711; y1Tg | Complex | Fig. 3 from Ferre-Fernández et al., 2020 | Fig. 3 from Ferre-Fernández et al., 2020 | ||
| foxc1amw711/mw711; foxc1bmw713/mw713 | Complex | 2 figures from Ferre-Fernández et al., 2020 | Fig. 4 from Ferre-Fernández et al., 2020 | ||
| foxc1amw711/+; foxc1bmw713/mw713 | Complex | 2 figures from Ferre-Fernández et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Ferre-Fernández, J.J., Muheisen, S., Thompson, S., Semina, E.V. (2022) CRISPR-Cas9-mediated functional dissection of the foxc1 genomic region in zebrafish identifies critical conserved cis-regulatory elements. Human genomics. 16:49
- Ferre-Fernández, J.J., Sorokina, E.A., Thompson, S., Collery, R.F., Nordquist, E., Lincoln, J., Semina, E.V. (2020) Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome. Human molecular genetics. 29(16):2723-2735
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