Genomic Feature
yku1
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 15: 2484883 - 2484886 (GRCz11) (1) Details
- Nucleotide change
- GCGC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 4 (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGATGACAGCACTTGCGTTTTAACAGCCTTTCATTTTGTTTTACGCTTGAACAAGCAAATTAAAGCTGAAGTCTATTTAACTGATTAAATTTCGATTCAATTATCGATGCTCTACAATGAACCTCACATTGACCTTTTTTTTTTGACCCTCATATTTACAGTAAATTTACATATACTGTAAATTTTTTTTTTTTCTTAAACTCTACTATTTTTTATATGTATATTTTATACTAATGTTAAGCACCTTGGGTCTGAGAGTAACGCAATTTCGATTCTCTGTATGTCTTGTACATGTGGCTGAATTGACAATAAAGCTGACTTTGACTTTCACCGGAAGTTTTATCAGTGGCTGAAACACTGTGCATGTAGCCCATTCCTGTTGCATACTTCTATCACTGATATGCTGTTATATTTGCATGTTTTTCCCCTTTCAGCTCTGTGATAGACCTCACTGAGAGCTATTTTAAATATCCTCTGGTGGAGCAGTACTTGAGGACCAA
GCGC/- TACTCTAAAGGATTACTGATCCGCTACCTTCTTTGCCGCACCATCACTGTCTTGGCCCTCACTCTAGCCTGCATCTACCTTTGCTATTACATCAGCCTCTCCACCACCGATGAGTTTTCGTGTGACATCCGCTCTGGTGTGGTTGTCAATGACTCCTCCGTGCCTCCAGCCCTGCAGTGCAAGCTAGTTGCTGTGGGCATCTTTCAGCTCCTGAGCTACATCAATCTTTCAGTGTATTTGCTGCTGTTGCCATTGTGCATGTTTGCCATGTTGGTTCCATTCAGAAGGACCAAGGGCTTCCTGAAGCCTTTCGAGATGTTGCCCACAATAGGTGTGATGCAGTTTGGGCAGGCGACCTGGGATGATCTTGCTCTGTATCTGCTGTTTCTGGACGAGAACCTCAGTGAGCTGAAGAGCTATAAGTGCCTTAAGGTGTGTTGATGAGGTTTTGTTCCATGGATTCCGGTAAGGAGTCCTCAGATACTTTTTAATGTCTGTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| panx1ayku1/yku1 | Homozygous | ♀+/- ♂+/- | 9 figures  from 2 publications | 4 figures from 2 publications | |
| panx1ayku1/yku1; panx1byku2/yku2 | Complex | 4 figures from Whyte-Fagundes et al., 2022 | 2 figures from Whyte-Fagundes et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Khalili, A., Safarian, N., van Wijngaarden, E., Zoidl, G.S., Zoidl, G.R., Rezai, P. (2023) Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research. 101(12):1814-1825
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
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