Genomic Feature
wcm6
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 20: 52953468 - 52953484 (GRCz11) (1) Details
- Nucleotide change
- CTGACAGTTTGTGCAGG/TTGTAAACCCAGTTT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 15 bp inserted / 17 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AACTTAGTTAATCAAATCCCCTATAGCACATGTGTTTGGACTGTGGGGGAAGCCGGAGCACACGGAGGAAACCCACACCAACACAGGGAGAACATGCAAACTCCACACAGAAAGCTTTGGACAAATTCTCAACAGATATAAAAAGCTAATTCAAAATCAATTGAAAAGGTTTTGACGTTCAGTTTACAATAAACAGTTGGGGATATCTGACAGCAGACAGGACACTCACCGGGTTTGGTTTTGCTGATGTTTTTGGGTTTGCGCTTTCGTGTCTGAATGCCCTCTTTCTTCATGGCGAGAGGACGAGGAACCTGAGCAGAAGAACAGCAGAACAAACACTCAGAGCTGTGGTTTTACTGGTTCTCTATCTCCATCTGCTGGACACATGTAGTACTGCAGATAAAGAGATTTCTGACCCCGTGGAGCTTCATGTAGAGTCCACAGGCGTTGCAGACTGGCTCTCCTTCTGCATTGCGTCTCCAAAGAGTTGTTGTGGTAGT
CTGACAGTTTGTGCAGG/TTGTAAACCCAGTTT ATAAACCCACCCGCCTGGACGCAGACTGAGAGAAAAAGGGGGAGAGAGCAGTGAGGAAGAGATGGAATATAGAGTGTAAACAGTGCAAATAAGCATGCAAAATAACATAAAGCATGGCAAATAACAGAAAGCACTACAATACGCATGCAAAATAACAATAAACATTACAGTAAGTGTGCAAAATAACAATACAAAATATGCAAAAATAATAATATTGTGCAATAAGCATTAAAAATAACAATAAACACTGCAATCAGTGCAGAAAATAACAATAAACAAAGGAATAGGCATGCAAAATACCAATAAACACTGCAAAAATTGTGCAAAATAACAATAATAAATGTGCATAAATAATCACTGCAAAAAATAATCACTGCAATAATCGTGCAAACTAGCCATAAACACTTTAATAAGCATAAAAAATAACATTGAACACTGCAATAATCATGCAAACTAGCAATTAACACTTCATTGACTGTGCTAAATAACAATAACCTTTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gata4wcm6/wcm6 | Homozygous | ♀+/- ♂+/- | 2 figures  from Sam et al., 2020 | 3 figures from Sam et al., 2020 | |
| gata5wcm8/+; gata4wcm6/wcm6 | Complex | Fig. 4. from Sam et al., 2020 | |||
| gata5wcm8/wcm8; gata4wcm6/+ | Complex | 2 figures from Sam et al., 2020 | Fig. 4. from Sam et al., 2020 | ||
| gata5wcm8/wcm8; gata4wcm6/wcm6 | Complex | 2 figures from Sam et al., 2020 | Fig. 4. from Sam et al., 2020 | ||
| gata6wcm7/wcm7; gata4wcm6/+ | Complex | Fig. 7. from Sam et al., 2020 | |||
| gata6wcm7/wcm7; gata4wcm6/wcm6 | Complex | Fig. 7. from Sam et al., 2020 | Fig. 11. from Sam et al., 2020 | ||
| gata5wcm8/+; gata6wcm7/+; gata4wcm6/+ | Complex | Fig. 6. from Sam et al., 2020 | |||
| gata5wcm8/+; gata6wcm7/wcm7; gata4wcm6/wcm6 | Complex | Fig. 6. from Sam et al., 2020 | |||
| gata5wcm8/wcm8; gata6wcm7/+; gata4wcm6/wcm6 | Complex | Fig. 6. from Sam et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
- Sam, J., Mercer, E.J., Torregroza, I., Banks, K.M., Evans, T. (2020) Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis. Biology Open. 9(6):
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