Genomic Feature
ku4
- ID
- ZDB-ALT-210322-1
- Name
- ku4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Long Zheng Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 8: 45277577 - 45277584 (GRCz11) (1) Details
- Nucleotide change
- CACTATCT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CAATAAAATCAAAAGATTGGCCAATTTAGTGTTTGGGGTTTCCTGGCTAAACTTGGCCAGCCTGATAGCCAATCTTCATTGATTACACATTTCACCAGTAAGAGCAGAGTGTGAAGGACTGCTAATTAGCAGAGTAATAGCAGTTTTGCTTAAAATATTGCAATGCATACAACATTATTGGTCACATATCAATATATATATATATATATATATATATATATATATATATATATATAATAACATAAGCTTACTAATTTTCCATAGCAGACAGGGAGAAGTGTTCTTGTATGCGTTGGTCGTAGTAACTTCAGCTGCTCGCAACACATATCCTCTCTTTTCTTCACCATGCTGACCGTTGAATTTATTATCATCTCTAGACTTGTGGGACAGGACACTGCTTGTTTAGCACTGTGTTGGACCAGCTCAAAGCTCTCTCCTTTGGTCTGAAACAAACACCTCCACAGTCCTTTGATAGACTCATTCCTTGAGCAGTTCACCCA
CACTATCT/- CAAAGGGAGGCACTGAAAAATATTGACTAATAATGTTAAGGTGTATACATGTTCACCTTTAAATATACTGACTTTATAAAGACAAAATAAACAAAGTAATGGCTTTTCTGTAAACCTTAACCCTGTTAGCCCGACTCCTCATTTGTGACCACTACTTCTATCGAATATGTGAATATCAGACTTACCTGATTTAGTAGAAATAGTATCAAAATAATAAAATAAATCTTGAGGTTTCAGTGAATCTAAAAAATCCTGGAGAGAAAAACAAATTCATTGTTGAAATTAGACAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGAAATTAAATATTTGGTTATTATTTTGTTAATTTTGGTTACTATTTAGGTTTCAAAAAACATTAATACATTTAAAGCCATATGATGGCGAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| adamts13ku4/ku4 | Homozygous | ♀+/- ♂+/- | 4 figures from Zheng et al., 2019 | Fig. 1 from Zheng et al., 2019 | |
| adamts13ku4/ku4; sd2Tg; y1Tg | Complex | Fig. 2 from Zheng et al., 2019 | |||
| adamts13ku4/ku4; vwfku5/ku5 | Complex | 2 figures from Zheng et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Zheng, L., Cao, L., Zheng, X.L. (2022) ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish. Journal of thrombosis and haemostasis : JTH. 20(10):2270-2283
- Zheng, L., Hill, J., Zheng, L., Rumi, M.A.K., Zheng, X.L. (2022) A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations. Journal of clinical and translational pathology. 2:108-115
- Zheng, L., Abdelgawwad, M.S., Zhang, D., Xu, L., Wei, S., Cao, W., Zheng, X.L. (2019) Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor. Haematologica. 105(4):1107-1119
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