Genomic Feature
zf3155
- ID
- ZDB-ALT-210120-4
- Name
- zf3155
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 23: 9533153 - 9533157 (GRCz11) (1) Details
- Nucleotide change
- GAGCT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CTTTTTGATTTATCTTTTCAAAATTTGTAGTTTTTTTTTTTCTTATTCAAAGAGCTTGAATTTCTAAGAAGTTCTGCATTTAAATTTCTTGAAAGCTCCTTCTAAGAAATCTTACCACTGAAAATGATTGACTAAACCTGTTACAGTCAAAAGAAATGCTTGTGGGGGTGCTTTATGTTCATACTGTCATATCTCACAGTAAAGACCACATGTCAAGTTGATTTCTTGGGAACATATCTTAAGACATTCATCTCATTCATTCATTAATTTTCCCCACATCCAGCTGGTTTTCTTAGGGGCCCCTTGAGAAACACGTCCAAACACAGTCTATTTTAACATGCGACTAAAGCAAGATAACTGTACTTCGTTTACTTTAAAATTGTCATTTCGCACAAAACTGTAAAACCGCAGTGGTCTTTGGTCCTGTTAAGTCTGTTTGATGTTGTCGTTTTCTAGGAGCTGTCCAAGATCACCATGCCCATTGTGTTCAACGAGCCCCT
GAGCT/- TTCTACAGAGACTTACTGAGTATATGGAGCACACATACCTCCTCCAGAAAGCCTGCTTACAGAGTGACTCCATAGAGAGGATGCAGGTGAGACCATTTCAAGGCATTGTAAAGAAGTTTTACATCTAAAAACAACAAGGGCTCCTATTTTACGACTTTCACAAGACGTAAGATAAGTGTTTGATGTCTTCAGAATGTGTCTGTAAAATTTCAACTCAAAGTATCTATCAGATTGATTATTATACAATGCAGAAAATGCCCATTTTGGGCTCAAAAGAAAGTGTAGGTCAGGGCTATGCAATTAGTTTGTCATGGGGGCCAGTTCATGAACAGCATCCCAAATGAGGGGCCGGAGAGAAATTACATCATATGAGTGATGACAGATAACAGCATCTAACAGCTCATATGTTGCACTTTTCCAGAAGACACCACATAGTATTTTTCTACAATAAATTCTTAATATGTTGTTTTTGAGACTACATAATATCAGTGCATTGTACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| osbpl2bzf3155/zf3155 | Homozygous | ♀+/- ♂+/- | 2 figures from Wang et al., 2019 | 3 figures from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Shi, H., Wang, H., Yao, J., Lin, C., Wei, Q., Lu, Y., Cao, X. (2019) Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues. Biochemical and Biophysical Research Communications. 521(1):42-49
- Wang, H., Lin, C., Yao, J., Shi, H., Zhang, C., Wei, Q., Lu, Y., Chen, Z., Xing, G., Cao, X. (2019) Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity. Cell Death & Disease. 10:627
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