Genomic Feature
sbu94
- ID
- ZDB-ALT-201201-6
- Name
- sbu94
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Sirotkin Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 5: 29619237 - 29619238 (GRCz11) (1) Details
- Nucleotide change
- -/TGTACCATACCTAAAAT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 17 bp inserted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TAAACATGTAAATATTAGCATTTTAAAATGCAATTTAATCTAATTACAATTCTGGATCAGGTATTACACAGCACTGCTTCTCAAAAACCTACAGACTCATTAAAAAAATACAATTACTTGCTATTTTACATCAAATGTTTACATTTATTTCTTTGCCAATTTTCAGCCCACATCCCAGAACTGACATACTGTAGGCTGTTATGATGAAAAAAGCCACATAAAAATAACCTTTGTGAACAAAATGACCCGTAATTACATGTCCTTGACAAGCTTAATTATATGCGTTGATTTTATGCTGTGTGAAATGTGCAATCTCTAAACGTGCTAATTTTCAGCCTTATTTGATATTCTGTTGTATAACATGTAGTACTGCTTCATATTTCCTGCTCACCCTAGGGTCGTTGATGCCGGTAATGCGCTCCTCAGGCCGATCCAGCACTAGGAAGGCTGCCAAATTGGCAGTATAAGATGCAACTATAATCATAGCAAAACCAGCCCACA
-/TGTACCATACCTAAAAT CCATACCTAAAATCCTCGCCGAAAAGCTCCGAGGGGCACCTGTGAATGGAAGCGTGGAGGTGAGAGCGATAATGAATATTATGCTTACTGCACAATCAATCAAACACTGAGTCAGCAATATCTGCACCTCACAGGGGGAAATGGAGCGAATAATAATTTGCTTGCTGATTTTTCTACCTTCTCCAATGCCGGAGTTCAGAAGTACACCCCAGGAGAACCACATAGCGGAGGATAAGGTGAGGGCGTCTTCTTCTTCCTCTTCACTATTCACTTTAAACCTTCCAAATGGGCTGCAGAGCGAAGCACATATCAGTCAGAGACAGACATTTCATACTTGTTAATCTGCAGTAAACCTTTTGGAATGTTCTGCAACATATTTAATACTGAGCTTCATTCTCACATCTGTACAGTCGGTTGGCTATTTAAAAAAATTGTCAGAGGATGAGTTTTAATGGAAATGCCCACTAAAAAAAGATTCAAATCCTGTCATTTAGAGACACT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| grin1bsbu94/sbu94 | Homozygous | ♀+/- ♂+/- | 4 figures from Zoodsma et al., 2020 | ||
| grin1asbu90/sbu90; grin1bsbu94/sbu94 | Complex | 6 figures from Zoodsma et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Napoli, A.J., Laderwager, S., Zoodsma, J.D., Biju, B., Mucollari, O., Schubel, S.K., Aprea, C., Sayed, A., Morgan, K., Napoli, A., Flanagan, S., Wollmuth, L.P., Sirotkin, H.I. (2024) Developmental loss of NMDA receptors results in supernumerary forebrain neurons through delayed maturation of transit-amplifying neuroblasts. Scientific Reports. 14:33953395
- Zoodsma, J.D., Chan, K., Bhandiwad, A.A., Golann, D., Liu, G., Syed, S., Napoli, A., Burgess, H.A., Sirotkin, H.I., Wollmuth, L.P. (2020) A Model to Study NMDA Receptors in Early Nervous System Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(18):3631-3645
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