Genomic Feature
pt527
- ID
- ZDB-ALT-201015-9
- Name
- pt527
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Beth Roman Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 21211266 - 21211273 (GRCz11) (1) Details
- Nucleotide change
- CACTGCTC/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GAGAGAGAAAGTAGAGAGCAAGAGTGAGAGAGAAAGAGAGAGAGAGGAAAAAACATTTGAAAAGAGATGGCACAGAGGGACATCTCTTTCACGTACTGAAACCACCCTCAAACTTTTCAGACATCAAAAGGTGAGAAGAAGAATAAATGCTCAGAGTTCAGGAATAGAGGCACTTTATTGCAGGCATCAGTGTGAGGCTACATATTGAACCAGAACAGCAAGGACAAGTCTACTATCTTAAGTTTTGCAGTGGAGCGTCAACTAAACTTCTGTCCAGGAAAAGTTGTGTACTGAAATTAAGTGCTTTTGATAGTGGATCTATAGATCTCACCTCCTGCACCTATAGCTAATACACATTTGTCTTGCGTCATGGCTGGTAGCAGAAATCACTTTTGGATTATATTTTCATCTGCCACGTCTGCTTTATTGGCCTTTTTCCTGCTTTTCTGGGGGCCTTTCTGTGTGCAAAGTAGCCCCATCAGCTCCCCGGAGAGGCACCG
CACTGCTC/- CAGGGTTGGATGATGGACATGGAGGCGTTTTGGATCCTTCACTCTTGGAGCAGGACAGTGAGGCGAACATGCAGAGCTTGATGGAGACCCTGAAGGGACAGTTTCTGCAGACTTTCAATCTGACCCGTCCCAGCTCTCCTGCGCATCAAGGGGCCACTCGTGTAGAGCCACCTGAGTATATGCTGGAACTCTACAACCGATTCGCCAATGACCGAACAGCAATGCCTTCGGCAAACATCATACGCAGCTTTAAAAATGAAGGTAACTGCATATTTTCCTATTCAATGAGGGCATTATAATCATTTGTATCGTAGGAATTTGTTATTTTTTTGTAAAAGAAAAAAAGAAAAAAACAACAACTTATTTTTCGACTGTTTATGTGATAAATAATGGTTTCCAAAATAATAATAATAAATGTAACGGTAACACTTTATTTTGATAGTCCATTTGAGTATTAGTAGACTGTCTGCTTAACATTCAACAGATATTTAACTGACTAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| bmp10pt527/pt527 | Homozygous | ♀+/- ♂+/- | 6 figures from Capasso et al., 2019 | 3 figures from Capasso et al., 2019 | |
| bmp10pt527/+ (AB) | Heterozygous | Unknown | |||
| bmp10pt527/pt527; f2Tg | Complex | Fig. 3 from Capasso et al., 2019 | |||
| bmp10pt527/pt527; hu5333Tg; hu7135Tg | Complex | Fig. 5 from Capasso et al., 2019 | Fig. 5 from Capasso et al., 2019 | ||
| bmp10pt527/pt527; la116Tg | Complex | ||||
| bmp10pt527/pt527; pt505Tg; twu34Tg | Complex | Fig. 3 from Capasso et al., 2019 | |||
| bmp10pt527/pt527; sd10Tg; sd11Tg | Complex | Fig. 3 from Capasso et al., 2019 | |||
| bmp10lsa11654/sa11654; bmp10pt527/pt527 | Complex | 2 figures from Anzell et al., 2024 | |||
| bmp10lsa11654/sa11654; bmp10pt527/pt527; la116Tg | Complex | Fig. 1 from Capasso et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Anzell, A.R., Kunz, A.B., Donovan, J.P., Tran, T.G., Lu, X., Young, S., Roman, B.L. (2024) Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. Angiogenesis. 27(3):501-522
- Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220
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