Genomic Feature
xu083
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 13: 25492827 - 25492836 (GRCz11) (1) Details
- Nucleotide change
- AGGCTGCAGC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 10 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AGCAGTGTTATTTCACAGACAACACCTACATACCATTACCCCTGAATTGTTTTTTTATGTCTTTAGTCATAGCCAAGCTATTGGAGCAAGTCAAAGAATTTCGCCATGATGCTTGTAATGACAGTATTGATAACTGGAGCTTATTCAATAACCCAGTCAACTGCATGCTTTTGTTATTTGCCTTCTCCAAAGCAATTTCACAGACAGCTACTAAATACTTCACAGCTAAAGAGTATCATCAGATGTGATGTTGTTTATCAGGCTTGTGTAGACCGGCGTATAAAGAATTGCTGGCATTACGGTGTGAAATATTTCACCCAATTGCAATGGAAAAGAGTTTGAACTGTTTACGTTTTCTTGTTTCAGATTTTTTCCAATGGTCCTTCAATGTCCCCAGAGACTCCTCAGGACATGCACAAAACCTTTATTAATGAGATGAGGCAGCCAATGCTCCGGCAGGGCTACATCCCCATCCCTGTCTGTCATGAAAACCCTGAACC
AGGCTGCAGC/- CAGTATCCTAGTTTCTCCTACATTCATCCAGCGGTGCAGCAGAATCTGAGAACAGATGGACGTACACCTTCCCCAACGCCAGCAGCACACTGTCGGCCTAGATCTCCAGTGCAGACCCCATCAGAAGCATGTTCGTCTTGCTCACCTACTTCACACGGGCCTGAGGTAAGATCATGAGAAAGCAATCTATAGAAGTGGCAGTCTCTGTCTTGGGTTTATTGGGAAAGGTTTGCATTAAGAGGATAGTTCACTGTAAAATTGGTTGTTAATTTACTTGCCCTTGGGTCATCGAATATGTCGCTGAGATTTTCTTTAGTAGGATTTTAAAGAAAATATTTAGCTAAAACAGCAAAAAAAGGATATCGAGGCAAAACAAAACAGATATCTCCTGTTGATATATTGAGGTTTCGTGAAACGTGAAACAAAACTTCAATCAGTGCAGGAAACTAAATATTATTTACTATTACATTTATGGCACAGCCTAAAGAAAACTTTTAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| bag3xu083/xu083 | Homozygous | ♀+/- ♂+/- | 10 figures  from 2 publications | 2 figures from 2 publications | |
| bag3xu083/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Ding et al., 2022 | ||
| bag3xu083/xu083 + CRISPR4-acta1a | Complex | Fig. 6 from Ding et al., 2022 | |||
| bag3xu083/xu083; ano5amn0136Gt/mn0136Gt | Complex | Fig. 1 from Ding et al., 2022 | |||
| bag3xu083/xu083 + CRISPR1-atxn2l | Complex | Fig. 6 from Ding et al., 2022 | |||
| bag3xu083/xu083 + CRISPR1-ddit4 | Complex | Fig. 6 from Ding et al., 2022 | |||
| bag3xu083/+; dnajb6bxu0411Gt/xu0411Gt | Complex | Fig. 2 from Ding et al., 2022 | |||
| bag3xu083/xu083 + CRISPR1-dnajb6b | Complex | 2 figures from Ding et al., 2022 | Fig. 4 from Ding et al., 2022 | ||
| bag3xu083/xu083; dnajb6bxu0411Gt/xu0411Gt | Complex | Fig. 1 from Ding et al., 2022 | |||
| bag3xu083/xu083 + CRISPR2-mtor | Complex | Fig. 3 from Ding et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Ding, Y., Wang, M., Bu, H., Li, J., Lin, X., Xu, X. (2022) An F0-based genetic assay in adult zebrafish for discovering modifier genes of an inherited cardiomyopathy. Disease models & mechanisms. 16(5):
- Ding, Y., Dvornikov, A.V., Ma, X., Zhang, H., Wang, Y., Lowerison, M., Packard, R.R., Wang, L., Chen, J., Zhang, Y., Hsiai, T., Lin, X., Xu, X. (2019) Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Disease models & mechanisms. 12(10):
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