Genomic Feature
fr26
- ID
- ZDB-ALT-200618-2
- Name
- fr26
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hammerschmidt Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 17: 2026449 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T in Exon 3 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GCCATTAGCCCCACAGCTCCCAGAACACAGTAAGTGTATTTCTACCCACACACTATAATCTGCTGCTTTACTCCATATAAAAGCCAGAAACTCTTTAGAACAGAACAATGTTAATGTTGCTAATTGATGAACGACATTAAAAATTAGACATTGTTCTTCCTTCCAAAAGGGAAAACTAGCAACAATCAAGAAAGCTTGATTATATGTGGTCATAACTTTGCAACCCAAAAATGTGACTATGATGGAAGTCAATCGGGCAAAAACAGCCACAAACATAATGAAAGGGATGTCAATTTGAACAATAAACAAGAAAACTGTTGATTACATCTCCTTGCAATGATAAAAATAATTTTTGGATATCTTATACTGGTCACCCACCGTCATTACAGCAGACGGGTCTCCGACCACTTGCTCCCATTCGTATTTCACAATCTTTTTATCATCCGAGCTCTCGATGCCATTGAGCGTCACATCTTCATTAGGTTGAACAACTCTGTCCT
C/T TCCGGCCCTTGCACGCGGAGGTCTATCCTCTACATCTGTATGGAAATAAAACATTGAAGTCACGAAATATGACGCAATCAGCAAACAAAGACACTGGGAATTGCACAAGACGCCAAGAATGAAATTAAACAAGAGTTTAATACAAGCTAGCTCTTGTGTGCTGAAGATCAGATTAGAGTTAAGAGACTATTAAGGAATCTCACATATCCAGACGTGCAGAGGATAGAAACAATGATACTAAACAGACTGCAAAAGGGGTTTCTATATGGTTGATATACCAGGGGCGCAGCATATATTATCAAATTTATGCATAGAGGTGTGCAATATTTATTGGTCATGATTATTCAGTATTCAATCATGAAGCATTTGTGTATTGAGGCAGGGGTTCTCAAACCTTTCAGCCTGCAACCTGCAAAAAATACCAATGCCAGTGACTTGTGACCCCAAGTATCCTCTGAGGTGGTTATAAATATAGAAACCATGTATGCAACAGCACGCAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| spint1afr26/fr26 | Homozygous | ♀+/- ♂+/- | 2 figures from Armistead et al., 2020 | Fig. 1 from Armistead et al., 2020 | |
| spint1afr26/fr26 + MO1-st14a | Complex | Fig. 1 from Armistead et al., 2020 |
1 - 2 of 2
Show
Supplemental Information
- Genotyping protocol
- None
- Armistead, J., Höpfl, S., Goldhausen, P., Müller-Hartmann, A., Fahle, E., Hatzold, J., Franzen, R., Brodesser, S., Radde, N.E., Hammerschmidt, M. (2024) A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms. Cell Death & Disease. 15:746746
- Ma, J., Scott, C.A., Ho, Y.N., Mahabaleshwar, H., Marsay, K.S., Zhang, C., Teow, C.K., Ng, S.S., Zhang, W., Tergaonkar, V., Partridge, L.J., Roy, S., Amaya, E., Carney, T.J. (2021) Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. eLIFE. 10:
- Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
1 - 3 of 3
Show