Genomic Feature

li17

ID

ZDB-ALT-200226-7

Name

li17

Synonyms

None

Affected Genomic Region

amer1 (1)

Construct

None

Type

Allele with one deletion (1)

Protocol

embryos treated with

Lab of Origin

Englert Lab

Current Source

Other Pages

Alliance

Notes

No data available

Genome Browser

Genome Build: GRCz11Chromosome: 5

Variants

Variant Type: Small Deletion
Variant Location: Chr 5: 22015903 - 22017169 (GRCz11) (1) Details
Nucleotide change: CTTCCATCCCTGGCGTGGTGGAGTCATAGTAACCCTCGTCACTGTTGGGTACCGACTCCTGCCGATCACTCTGTGGACTCAAGAGGTCGGCAGGAGTGAGAGCAGTTTCTGTGATTCCCATTGGGCTGCTGCTGGAGGTGGCACGGATAGAGCTCAGTTGCTGATCAGGGGTGAGTGAAGGGCTATCTGAGCCCCTATCTGAGGGGATGTAGCAGACTTCATTACTAGTTTCTGACTCCCATAAGCTCTGCAAGTAATCCGCGTCTATCTCATCCGGGGTTGCCATCTCTTCCCCCCCACCTTGATATGTGACAAAACATGAGCTACGTTTTCCTGCATTTCGACTGCCTCTGTCAGCAGACACTGAGCTCTCGGCGACACTGACATCATCCTGGTCTGCAATGATATCTCCACAACCGGTCAGCGAATCAAAGCTCTTTAATGATGACACATCACCAAAGACTAAGTTCTCAGAGGAGCAGGATGCAACAGGTGGCTCTCCATCAGGAACGTCCACATTTTGCTCAGCCAAACGATCCAATTCAGACTCAGCAGACAAGGGTTGATGATATGTCATCAGTCCTTCCTGTCTGCCAGTTTTCTCATCTTCTCCAATCCCCTCTTCTTCTGCTCTCCTCCTCTTATCCATCTCTACTCTGCTCCTCCTTTTTTCAGGCACTAGTGTTACATCTATCGTACATTCAGTGGCAGCCAAAGGCAGTTCACACTCACTGCCTGTGGTTTGATTAGGCACATCTGGCACCAGCTCTTCACCCTGACTGTCTCCATGGTAATCGCCACGGTCACTGACACTCGGCAGGGCACCAGGCACTGTTTTGGCATGGAAGCTTGAAGACATTTCAAGTGCTTCCCGCTTTTCTACTTCAACATTTTTGTTTTTCCTGTGTCTCCGAATGCTGCTGAAAAGTCCTCGAAGGCCCCTGCGCTGTCTAGGCAAAGACTGTGACTTCCCATGATCCTCCTGTGATTTCTGAGGTTCACTGCAGAACTCAAAGTCCCCTGATGCCACTTCACTGCTACTTCTACCCAAATCATCCCAGCATGCTCGGCTCACCCCATCATATGTCTGGCTTTTTGTTACTCCTGTTTTTGATGACCCCTTTCTTTGACTTCTGCCACGGCCTCCAAAAAAGCTAGGTAGAACACATATGCTTTTGCGACCTCCAAAAAATTTGAAAGCTGTCTTCCGTATTTTCACAGAAGGGGGTGACTGTGGTTGAGGGATATCATGGGAAACGGAGTCTGA/-
Variant Notes: wtx53_1315del1263 (c.53_1315del1263;
p.D18_E439del)
Große et al., 2019

Effect on DNA/cDNA, transcript, protein (from publications)

DNA/cDNA Change: None
Transcript Consequence: None
Protein Consequence: None

Sequences

Flanking Sequence: CACCGAATCAGCACAGGGTGCGAATAACGAACTCTCTTGAACCTGACCCCTGATGCGAGGGACTCCCTCTTTAACAGCCTGGGATCTTGGTGGGGATTGGGGATAGCGCTGATTGATAACTTCTTGCAAATCTTGCTTACTATCATCAACTGGAAGGTTCGAATCATCATAAAAGCAGTCGGAATGGAACAAAAGCTGGTTTTTGGATGGACTCCTGAGATTCTGAAGCTCACAGCACAGAAGGGCATGTTGGATCTTGCTCAGGCGCTCCTCCTCTGTCTCCATGGCTCCTGTTTCTATTGCAGTAGATGCCAAGGAGTATAGCGGGTTTGTTGGACTCTTATCAGCCTGCAAGGGTGCACCAACAAATGAGTGGGCATCCTTGGGAGGAAGAGAAGGACTGAGCAGGCGATCGTCAGGCTCAAAAAGTTCATAAAGGGCATCACCACTGTAGCTGTCCCGTGGAAGCCTTTCCTGGTGTGGACGTTCTCTACTCTCCT
CTTCCATCCCTGGCGTGGTGGAGTCATAGTAACCCTCGTCACTGTTGGGTACCGACTCCTGCCGATCACTCTGTGGACTCAAGAGGTCGGCAGGAGTGAGAGCAGTTTCTGTGATTCCCATTGGGCTGCTGCTGGAGGTGGCACGGATAGAGCTCAGTTGCTGATCAGGGGTGAGTGAAGGGCTATCTGAGCCCCTATCTGAGGGGATGTAGCAGACTTCATTACTAGTTTCTGACTCCCATAAGCTCTGCAAGTAATCCGCGTCTATCTCATCCGGGGTTGCCATCTCTTCCCCCCCACCTTGATATGTGACAAAACATGAGCTACGTTTTCCTGCATTTCGACTGCCTCTGTCAGCAGACACTGAGCTCTCGGCGACACTGACATCATCCTGGTCTGCAATGATATCTCCACAACCGGTCAGCGAATCAAAGCTCTTTAATGATGACACATCACCAAAGACTAAGTTCTCAGAGGAGCAGGATGCAACAGGTGGCTCTCCATCAGGAACGTCCACATTTTGCTCAGCCAAACGATCCAATTCAGACTCAGCAGACAAGGGTTGATGATATGTCATCAGTCCTTCCTGTCTGCCAGTTTTCTCATCTTCTCCAATCCCCTCTTCTTCTGCTCTCCTCCTCTTATCCATCTCTACTCTGCTCCTCCTTTTTTCAGGCACTAGTGTTACATCTATCGTACATTCAGTGGCAGCCAAAGGCAGTTCACACTCACTGCCTGTGGTTTGATTAGGCACATCTGGCACCAGCTCTTCACCCTGACTGTCTCCATGGTAATCGCCACGGTCACTGACACTCGGCAGGGCACCAGGCACTGTTTTGGCATGGAAGCTTGAAGACATTTCAAGTGCTTCCCGCTTTTCTACTTCAACATTTTTGTTTTTCCTGTGTCTCCGAATGCTGCTGAAAAGTCCTCGAAGGCCCCTGCGCTGTCTAGGCAAAGACTGTGACTTCCCATGATCCTCCTGTGATTTCTGAGGTTCACTGCAGAACTCAAAGTCCCCTGATGCCACTTCACTGCTACTTCTACCCAAATCATCCCAGCATGCTCGGCTCACCCCATCATATGTCTGGCTTTTTGTTACTCCTGTTTTTGATGACCCCTTTCTTTGACTTCTGCCACGGCCTCCAAAAAAGCTAGGTAGAACACATATGCTTTTGCGACCTCCAAAAAATTTGAAAGCTGTCTTCCGTATTTTCACAGAAGGGGGTGACTGTGGTTGAGGGATATCATGGGAAACGGAGTCTGA/- CGATGGACCCCTCATTGCACCAACCTCACATCTTGTGGCGATCTCCATAATGACACAGGTGACTGTGGCTAATGGAGCAT ...
Additional Sequence: None

Fish

Show only fish without sequence targeting reagents

Fish	Genomic Feature Zygosity	Parental Zygosity	Affected Genomic Regions	Phenotype	Gene Expression
amer1^li17/li17	Homozygous	♀+/- ♂+/-	amer1	Fig. 3 from Große et al., 2019	Fig. 4 from Große et al., 2019
amer1^li17/li17; li1Tg	Complex		amer1		Fig. 3 from Große et al., 2019
amer1^li17/li17; amer2^li18/li18; amer3^li20/li20	Complex		amer1 amer2 amer3		Fig. 6 from Große et al., 2019
amer1^li17/li17; amer2^li18/li18; amer3^li20/li20 + MO3-amer1	Complex		amer1 amer2 amer3		Fig. 6 from Große et al., 2019

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Supplemental Information

Genotyping protocol: None

Citations

Include unpublished citations

Große, A., Perner, B., Naumann, U., Englert, C. (2019) Zebrafish Wtx is a negative regulator of Wnt signaling but is dispensable for embryonic development and organ homeostasis. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(9):866-881

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