Gene
amer1
- ID
- ZDB-GENE-070719-2
- Name
- APC membrane recruitment protein 1
- Symbol
- amer1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; caudal fin; central nervous system; digestive system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer and osteopathia striata with cranial sclerosis. Orthologous to human AMER1 (APC membrane recruitment protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteopathia striata with cranial sclerosis | Alliance | Osteopathia striata with cranial sclerosis | 300373 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR019003 | APC membrane recruitment protein |
Domain Details Per Protein
| Protein | Length | APC membrane recruitment protein |
|---|---|---|
|
UniProtKB:A0A2R8RN23
|
953 | |
|
UniProtKB:F1RDM5
|
930 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available