Genomic Feature
zf2203
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 1: 51038511 - 51038517 (GRCz11) (1) Details
- Nucleotide change
- GGGCCGC/TT
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted / 7 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Cys>Stop at position 68 (1)
- Flanking Sequence
-
TCAAAGGATGAGGTAAAGTTGTTTCTATTATCACACGTTCAGACTTTTTCCTTAATAATATAATTTTAAAAAAGTATTATTTGCAAATCCTAAATAGGGAAACTATATTAGCAACAACGACTATCTAATTACAACATTGTTCAGAGTCAATTAAATAGTGCTAATGTTGCTCTGAAGCCATACTTTCAAGTAATTTCAGACCAAATATTCAAAGTAGCATGGTAAACAATATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTTTTTTTTTTTTTTATCAGATTAATCGATTAATCAAAAAATAATCGACATATTAATTGATTATTAAAATAACCGTTAGTTGCAGCCCTAACCTCAACAGATATAATGTCAGGTACCTTTCTCGTCCTCGTCGATCTGCAGAGCCACAGAAATGAACTCGAAGGCTTGTTTGTGGTAGTTTCGGATCCGCTCTCCGGTCTCTTCACTGCCGTCG
GGGCCGC/TT ACTCTTTGGCCCGGGCCGCCATGGCTCGTCGAATCGGCTGAAACAGCCACCGAAGAAGCAGCAGCAGCACCCGCAGCAACCACTCCGGGACCCTGGACAGGGAGCGGGTGTAAAAGAGCAACCGGTTCCCCCGCGCGCTCCCGTCAGACACCGGACCGCAAGCGCGTCCTCCTCTGAGTCTCGCTTTGTGCCCAGAATTCATTCACCCTTCTCGGGCTCTCCATACCATAACGGGCCGGGAGTTTGGGGAAAGGAGAGTTTATTCCAGGGCGATGTCCGGCTCTCTGGTTTGTTTTCGCCTATATCGATCGCGGAAGTCTGCTGTTTGTGTGTTTGGAGCAAACCAGTCTCGCGCTGATGACGTCAAAGAAGTCGCAAGCGCGTATTTATTTATTTATTTATTTATTTATATATGTATTGTTTTATTTATGCAGGAATTTGTGTATTTATATTCATTAATTTTTTTTATTTGCGTATTTATTTATTTATTGTTTTATTTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| spastzf2203/zf2203 (TU) | Homozygous | ♀+/- ♂+/- | Fig. 5  from Jardin et al., 2018 | ||
| spastzf2203/+ (TU) | Heterozygous | Unknown | Fig. 5 from Jardin et al., 2018 | ||
| spastzf2203/+; ml2Tg (TU) | Complex | Fig. 5 from Jardin et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Ten Martin, D., Jardin, N., Vougny, J., Giudicelli, F., Gasmi, L., Berbée, N., Henriot, V., Lebrun, L., Haumaître, C., Kneussel, M., Nicol, X., Janke, C., Magiera, M.M., Hazan, J., Fassier, C. (2024) Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes. The EMBO journal. 44(1):107-140
- Jardin, N., Giudicelli, F., Ten Martín, D., Vitrac, A., De Gois, S., Allison, R., Houart, C., Reid, E., Hazan, J., Fassier, C. (2018) BMP- and Neuropilin-1-mediated motor axon navigation relies on spastin alternative translation. Development (Cambridge, England). 145(17):
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