Genomic Feature
bns241
- ID
- ZDB-ALT-190813-6
- Name
- bns241
- Synonyms
-
- vcla?13 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 13: 25238627 - 25238639 (GRCz11) (1) Details
- Nucleotide change
- CCGGGTCCCAAAA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 13 bp deleted in Exon 8 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AATCTGCTTTCCCTGAGTCTCCCTAATGAAGTCAGAGCCCGCCGTCTGATCTTTCACTTTCACTCTGGTTTTCAACATCCCTGACACAAGAGCCCAAAAACTGTACCACATTGTTCCTTCCTTCTCCTGTACTCGGCAGTCAGGGATAAACAATCCCTGGAGAATTAAACTGCAAACAAACAACGTCTAAACTGTGTTCATTGGAAACCCTGACACACTTTCTTGTGTAGTAAATTAGAAGCAGTTACGGCCCCAGAGACGCACATCACACAGGGGTAAACGTGTTGCATAAAGGATGATGAATATGATTATGAACAGCATTAATGCATAATTCAGCTCACGCTACAGGAACATGTGCAGGCACTTTTTGGTCTCTGTGTGAAATGATCTGAATCAGCACTGTGTCAGGCTCTGGTTTTTGAGTTAGAGTGTTGTGCTGGTGCTCCAAAAGAGGGCGTTCGGGTACCTGGCGCGCACATCTGACACCTGATCCGTCATCT
CCGGGTCCCAAAA/- GGCTGTTCCCAGGATCTCTCGTCTCTCTTTCCCTGCACAAAGCTCACCCACTTTTCCTGCTTCATCCAGGATCTGACGCAGCGCATGCTCTCCTGGATCTCCTGGGAGAAGACATCCAGAGGGAGTGTCACAGAAATTAGGCCACAACACATACATTACTTAATTTTTTTGTATTAGTATTGTTATTGTTTTTAAAGTATAATTAACTATGATGATATCATTAACATTTTAGTTTTGGTAACACTCACAAGAAGGTGAAGTTGTTTGAAATTTCTAGTTAATTCATTTGATAACATGAACAGACAAAGCAAAAGTGAATGAAATGAAATAAATAAATGTTTATGTTTGTTCACAGTTAAGGAGGGGGTGGGGGGTGCTTGTTGACACCAGTGACACCAGTTGACATCAGTGCCCCCGTGTCAACAAGTTTGGCCCTCCCTCTGCCCCCCCTAAATTTGGACCCGTATTTTTGTGTCGAAACCAAAACACGGAGAAGCGAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| vclabns241/bns241 | Homozygous | Unknown | 3 figures from El-Brolosy et al., 2019 | ||
| vclabns241/+ | Heterozygous | Unknown | Fig. S2 from El-Brolosy et al., 2019 | ||
| vclabns241/bns241; upf1ya3319/ya3319 | Complex | Fig. 2 from El-Brolosy et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- El-Brolosy, M.A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G.L.M., Takacs, C.M., Lai, S.L., Fukuda, R., Gerri, C., Giraldez, A.J., Stainier, D.Y.R. (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751):193-197
- Fukuda, R., Gunawan, F., Ramadass, R., Beisaw, A., Konzer, A., Mullapudi, S.T., Gentile, A., Maischein, H.M., Graumann, J., Stainier, D.Y.R. (2019) Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis. Developmental Cell. 51(1):62-77.e5
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