Genomic Feature
ouc2014
- ID
- ZDB-ALT-190528-11
- Name
- ouc2014
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Chengtian Zhao Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 16: 16758608 - 16758609 (GRCz11) (1) Details
- Nucleotide change
- AG/GAGGGATTATAAATCCCTCCTAAAATCCTATAAATCCTATAAATCCCTAAAAAA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 54 bp inserted / 2 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TCAAGGTGCAAAGTAATCATCATGGGCAAACTGAGAGCGATGGCAAAGCCCCAGGCCAAAGCGACTCTTAAAAGTCCAGAGGATGGTGTGGATGTGGTTGCCAATGGATCGGCCACAGCTCGATACCGATCCAGACTCATAGCGGTGAGGGTAAAGATGCTTGCGTGCATTGTTAACAAGTCCAGACTGAGTAGGAGTCGACAGCCAAGTTCGCCAAATGCCCAGTCAGATGCCAGACTGTCATACACAATGAAAGGGGCAGTGGACAGGTACACCAAATCTGCTAAAGCCAGACTCAGAACCTGCAGGTGAAGAGAGGAAGAGGAGGAGGAAGATGTGGGAGAGGAAGATGGAGAAAAAGAGGGAGAGAAAGAAGGGGAGGAAGAACCGAGGCAGGACAGACTGTAACAACACATAGGAGCAGTATGCCGCCTTCTTGACATTCTGCGGCGGCGAAGGAGAAGTACTAGGGTGTACAAGTTGCCCAGAATACCCAACAG
AG/GAGGGATTATAAATCCCTCCTAAAATCCTATAAATCCTATAAATCCCTAAAAAA AAAGGAGGGATAGGAAAAAGCAGAAGAGAGCAGTGGAAGCTACACTTGGGGATGGGGAGAGAGAGGGTGATGATGAGGGAAAGGAAAGGTTAGTGAAAAAAGGAAAGGTGTATGAAGGTGAAGGGGAAGAGAAGAGGGAAGTAGAACCAGGTATATCCATTTGTCCTGGAGAGCAAGAGTCTCAAAATGAGTAACCTTCCGATGAAATAAGGAGGCCAATGCAACGAGTGTTTTAGATGAACTACTGTATCCAGGACATCAGGGGATCCATATTAGAATGGGAGATCTGAGAGCAGATTAATAAAGGTAAAAGAGGGGAAACAAGAGAAAATGAAATAGTGATTTTATAAACTTGTATTAATTATGAGGCTTGTGCAAATTATGACATTGATATTAAACACTGATATTGAATAATTTGAACAATTTCACACAAAACTTCACATAAAACTTGACCATAGAGCAAAACTAGTGAAAAACTAAATAAATAAGCTTCCATAAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| uts2r3ouc2014/ouc2014 | Homozygous | ♀+/- ♂+/- | Fig. 4 from Zhang et al., 2018 | ||
| uts2r3ouc2014/ouc2014 | Homozygous | ♀-/- ♂+/- | |||
| uts2r3ouc2014/ouc2014 | Homozygous | Unknown | Fig 8  from Xie et al., 2023 | Fig 8 from Xie et al., 2023 |
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Supplemental Information
- Genotyping protocol
- None
- Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
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