Gene
uts2r3
- ID
- ZDB-GENE-100922-123
- Name
- urotensin-2 receptor 3
- Symbol
- uts2r3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable urotensin II receptor activity. Acts upstream of or within notochord morphogenesis and skeletal system morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in integument; muscle; pleuroperitoneal region; somite; and spinal cord. Used to study idiopathic scoliosis.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1436 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| mhn5 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ouc2014 | Allele with one delins | Unknown | Unknown | TALEN | |
| sa6418 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16966 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-uts2r3 | (2) | |
| CRISPR2-uts2r3 | (2) | |
| CRISPR3-uts2r3 | Bearce et al., 2022 | |
| MO1-uts2r3 | N/A | (2) |
| MO2-uts2r3 | N/A | Zhang et al., 2018 |
| TALEN1-uts2r3 | (2) |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| idiopathic scoliosis | uts2r3ouc2014/ouc2014 | standard conditions | Zhang et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
| UniProtKB:F1QSR0 | InterPro | 386 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-27n14.1-201
(1)
|
Ensembl | 1,906 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27N14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005157928 (1) | 1817 nt | ||
| Genomic | GenBank:BX322544 (1) | 68718 nt | ||
| Polypeptide | UniProtKB:F1QSR0 (1) | 386 aa |
No data available
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
- Bearce, E.A., Irons, Z.H., O'Hara-Smith, J.R., Kuhns, C.J., Fisher, S.I., Crow, W.E., Grimes, D.T. (2022) Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology. eLIFE. 11:
- Alejevski, F., Leemans, M., Gaillard, A.L., Leistenschneider, D., de Flori, C., Bougerol, M., Le Mével, S., Herrel, A., Fini, J.B., Pézeron, G., Tostivint, H. (2021) Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Open Biology. 11:210065
- Quan, F.B., Gaillard, A.L., Alejevski, F., Pézeron, G., Tostivint, H. (2021) Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. Peptides. 146:170675
- Roy, S. (2021) Adolescent Idiopathic Scoliosis: Fishy Tales of Crooked Spines. Trends in genetics : TIG. 37(7):612-615
- Wang, X., Wang, S., Meng, Z., Zhao, C. (2020) Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 47(12):781-784
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
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