Genomic Feature
zf1061
- ID
- ZDB-ALT-180614-2
- Name
- zf1061
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 3: 56705210 - 56705211 (GRCz11) (1) Details
- Nucleotide change
- -/GC
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp inserted in Exon 2 (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- None
- Flanking Sequence
-
AGTAAACTTTGAGTTGAAATATTGTTCTGTTACAGAATGTACACATTTCACTTAATAAACAACAACAACATTTTAAAAGGGTTTATTAAAAGAGTTTGTGGAGTTTGCATTTATCAAAGATTGACCTTTAACACACACTCTGTACTAAATTGATGTACAATACATTCATTCATTTTCTTCCGCTTACTGTAGGTGACCATAAAGTCATTGTAGCTGACTCATTGCATTTATTCACAGCATGTGATTTTCACTCTGTATTTACAGACTCCCCTCCCATTGTTAATTTTTAATTTTAAGAAAACTGAAATCGAAAGCAATTCCTTTTTGCTTTTGCTTTTGAAAGCAGTTCCTGGAACTCATGTGACTGTATGTTTTCTTGTCATGTTATGGAGGAGTTACTTCATACTTGTGCTCTTCCCCATAGAATGAAGTGTCCTAAGTGCAGTCACGAGGCTTTGGAAAAGGCCCCAAAGTTCTGCAGTGAGTGTGGACATAAACTGC
-/GC AATCTCAATCTTACGAGACAACACAAGGTACTGTAGAGTCTTTAGATTCATTATGTCTTCTTACACATAGAAATTCTTACTTTGTTGTCTGCTCTTTCATTGGTTTGCATAAATGCTTTGGCATGCTTTTATTGATGTTCACTTTTGAATTCATTTTATTTCTGTTGACGTTTAATTGGATAATAAAAGGAGGTAAAACTGTACTTTATTATTTCCGTTTAACATTCTTTAGTTGGACTTTTGACCCCCTGACTTTTTATTATGTGAATTTTTTTACCTCACTGTTTGTCATTTTTCTCTGGCTGTTCAGTATTCAGCATAGTAGTTACATGTATTGTAAAAAAAAATAATAAGTAAAGAAATAGGAAATGTAATCAGGTGGTATTGATTAACTTTTGATGGTAATAATAATGGTCTATTAATCTTAATTAATTAAGTATTGATTAATCTGACTTCATGTAGCAAAATTTTTGGTCACACTTTACAATAAGGTTCATTAGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rnf213azf1061/zf1061 | Homozygous | ♀+/- ♂+/- | |||
| rnf213azf1061/zf1061; sd2Tg; zf531Tg | Complex | Fig. 3 from Lin et al., 2020 | Fig. 4 from Lin et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Lin, J., Liang, J., Wen, J., Luo, M., Li, J., Sun, X., Xu, X., Li, J., Wang, D., Wang, J., Chen, H., Lai, R., Liang, F., Li, C., Ye, F., Zhang, J., Zeng, J., Yang, S., Sheng, W. (2020) Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 41(6):1251-1263
- Wen, J., Sun, X., Chen, H., Liu, H., Lai, R., Li, J., Wang, Y., Zhang, J., Sheng, W. (2016) Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish. Brain research. 1644:70-8
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