Gene

rnf213a

ID

ZDB-GENE-050302-100

Name

ring finger protein 213a

Symbol

rnf213a Nomenclature History

Previous Names

rnf213
mysterin a (1)
RNF213 alpha (1)
wu:fm55d09 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Involved in blood circulation and sprouting angiogenesis. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human RNF213 (ring finger protein 213).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rnf213a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Moyamoya disease	Alliance	{Moyamoya disease 2, susceptibility to}	607151

Associated With rnf213a Via Experimental Models

Human Disease	Fish	Conditions	Citations
cerebral cavernous malformation	rnf213a^{zf1060/zf1060}; sd2Tg; zf531Tg	standard conditions	Lin et al., 2020
cerebral cavernous malformation	rnf213a^{zf1061/zf1061}; sd2Tg; zf531Tg	standard conditions	Lin et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR046439	Zinc finger, RZ-type
Family	IPR031248	E3 ubiquitin-protein ligase RNF213
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	E3 ubiquitin-protein ligase RNF213	P-loop containing nucleoside triphosphate hydrolase	Zinc finger, C3HC4 RING-type	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site	Zinc finger, RZ-type
UniProtKB:A0A0R4IBK5 InterPro	5209

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rnf213a-201 (1) Ensembl	Ensembl		16,192 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations