Genomic Feature
bns102
- ID
- ZDB-ALT-180612-4
- Name
- bns102
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 37854895 - 37854910 (GRCz11) (1) Details
- Nucleotide change
- AGCACTAACCCAGGCA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 16 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TCATTCTGTGTAAACTTGTGTTCTCAACAATTAACAATTAACCAAAAGCCTCTGGAGCTGCGTGAGCATCACGATGTGTTTGTCTTCTGTGAGCGTGGCAGTGTCCACGAAGTCAATGTGAATTGGTTGGCCAAACACAGCTAATGTGGCATGTGTGATTGGACAGCCACTTAAAAGTGTTAAAGTGTGTTTACGCACAGGATTGGTTTTCCGCTGAATCAGGCAAAACCAGCAGAACCGATCTAAACTCGAGTATAAAAGTGAGTAGGAGATGCTATTCGTCCCAAAACATCTCCACCACCATATCCACCATTCCTCGCCTCTGCTTCGAGAACAGGTGAGTGTCGAGCGGGATGGTAAATCTACAGAGAATGCGGAGTGTAGCTTGTGTACATGTTTTTGATTAACAGAGATTGTATGTGTGTGTTTGTGTCAGTGTGACCATGGCAGTGTGGCTTCAGGCTGGTGCTCTGTTGGTCCTGTTGGTCGTGTCCAGTGTA
AGCACTAACCCAGGCA/- CACCGCAGCACCTGTGTGGATCTCATCTGGTCGATGCCCTTTATCTGGTCTGTGGCCCAACAGGCTTCTTCTACAACCCCAAGAGAGACGTTGAGCCCCTTCTGGGTAAGAAAGTCAAGTAGAGGTGTTTTGACAGTGGAGTAGTAACAGTGGAGTTTTATCATTTTTAAATCCAATTAGCGATCTCCAACTCTGGCAAGAGCACTTTTAGTTTAGTTTAGCGTAGATCATTGAATTGAATTAGACCATTAGCGTCTCGTAAATTTTTTTTTTTGATAATTTCCCTATTGAGTATATAGCTTGAAAATGATAACTTTACTATTCTTTATTTACATTGTGGACTAAGACCAGTGGAAATGAAATGTTGCTGCTTTCTACACTGTAAAAAGCGATTAGTTGCCTTTACCTAAAAAAAGAGAGTGAACTCGTTGCCTTATAATTAAGCAAACTATGTGCATATTATAAAAGTTAAGTCAATGGGTTTTCTGACTTTTTAAAAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| insbns102/bns102 | Homozygous | ♀+/- ♂+/- | 3 figures  from Mullapudi et al., 2018 | Figure 4—figure supplement 1. from Mullapudi et al., 2018 | |
| insbns102/bns102; zf5Tg | Complex | Figure 1 from Mullapudi et al., 2018 | |||
| insbns102/bns102 + MO1-ar | Complex | Fig. 4 from Mullapudi et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Ren, L., Charbord, J., Chu, L., Kemas, A.M., Bertuzzi, M., Mi, J., Xing, C., Lauschke, V.M., Andersson, O. (2023) Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis. Diabetologia. 67(1):137-155
- Helker, C.S.M., Mullapudi, S.T., Mueller, L.M., Preussner, J., Tunaru, S., Skog, O., Kwon, H.B., Kreuder, F., Lancman, J.J., Bonnavion, R., Dong, P.D.S., Looso, M., Offermanns, S., Korsgren, O., Spagnoli, F.M., Stainier, D.Y.R. (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development (Cambridge, England). 146(14):
- Mullapudi, S.T., Helker, C.S., Boezio, G.L., Maischein, H.M., Sokol, A.M., Guenther, S., Matsuda, H., Kubicek, S., Graumann, J., Yang, Y.H.C., Stainier, D.Y. (2018) Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists. eLIFE. 7:
- Matsuda, H., Mullapudi, S.T., Zhang, Y., Hesselson, D., Stainier, D.Y.R. (2017) Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval to Juvenile Transition to Maintain Glucose Homeostasis. Diabetes. 66(10):2623-2635
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