Genomic Feature
m1435
- ID
- ZDB-ALT-180425-3
- Name
- m1435
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Onichtchouk Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 24: 12836301 - 12836310 (GRCz11) (1) Details
- Nucleotide change
- GCATATGCAT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 10 bp deleted in Exon 1 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CCACACTATAAATACACAACTTAATTATAATGTGTATCTTTTGTAAAGCTGCTTTGGAATGATAATTATTGTGAAAAGCACCATATAAATAAACTTCAATTGAATTAAATAAAATAACTGCAACGAGTAGGCCTATTATTCTTAGGTAAGTGTGGAACGAGAGTGTGTTTGTTTCACTAAAAAGCTGCATCTGATTGGTCCTTGCAACTTGCCGTCGCTCTAAACCCGCCCACAACCACTCACCTGGCAATATAAATCAGCATATCCACACATTTTTTACATCAGGTGATGTAAATGGGTCGGTAATTGTTACTATGAGGAGGAGCGCTTCAATCAGCATCCGTTTTCGAGGGTAGTCGAGCCCTTTGGGTTTTTTTTTTTAGTAGTCCGGTTTTTTTTAATTAGGTGTTTAGTACGTTACTTTCTGCTTGAGTTTATCTAACGGCGAAATGGCGGACTGGAAGATGCCAGTGAGTTACAATTTTAACCCATCTTATCAT
GCATATGCAT/- ACGGGCTCATGTACCCGCAAGTGTCAGAGCACGGCGTCCCGAATCTGAGCTGGCCCGATGCCGCGTACACACACTCCGGCGGGGTCACAGCGGGCTACTTTACCGCTCAAACTGCACAGTCGCCACCCTGGAGCCCGGAGAACGGCGGCGCCAGCAGCACCTACAGCCAGTACCCGGGACACTCGCAGAACGGACGGCTCTTTCTGTCCTACAACAAGACTGAGCCCGACCAAAAGGCCAAAGATGCAGAGCAGACCAGCAGTGATACACCCAGTGATTCCGAGGCCCACACGCCAGGTAAGCCTTCACTGACCGAAAGTTAACACGGTGCGGTGTCATGCGTACACTCGACTCGATAAAAGCAAACTTCTCCATGTTTTGAGAGTTTTGGTCTTCCTGGCCATCCTTGACACAACGCGAAAGGGGCGAAATCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTATTTTTAT - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
nanogm1435/m1435 | Homozygous | ♀-/- | 2 figures from Veil et al., 2017 | 2 figures from Veil et al., 2017 | |
nanogm1435/m1435 | Homozygous | ♀-/- ♂+/- | Fig 4 from Pálfy et al., 2020 | ||
nanogm1435 | Unknown | ♀-/- | 2 figures from Veil et al., 2017 | Fig. 3 from Veil et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Riesle, A.J., Gao, M., Rosenblatt, M., Hermes, J., Hass, H., Gebhard, A., Veil, M., Grüning, B., Timmer, J., Onichtchouk, D. (2023) Activator-blocker model of transcriptional regulation by pioneer-like factors. Nature communications. 14:56775677
- Pálfy, M., Schulze, G., Valen, E., Vastenhouw, N.L. (2020) Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation. PLoS Genetics. 16:e1008546
- Veil, M., Yampolsky, L., Gruening, B., Onichtchouk, D. (2019) Pou5f3, SoxB1, and Nanog remodel chromatin on High Nucleosome Affinity Regions at Zygotic Genome Activation. Genome research. 29(3):383-395
- Veil, M., Schaechtle, M.A., Gao, M., Kirner, V., Buryanova, L., Grethen, R., Onichtchouk, D. (2017) Maternal Nanog is critical for the zebrafish embryo architecture and for cell viability during gastrulation. Development (Cambridge, England). 145(1)
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