Genomic Feature
su3
- ID
- ZDB-ALT-170830-2
- Name
- su3
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Lewis Lab - Syracuse
- Current Source
- Other Pages
Notes
| Comment | Citation |
|---|---|
| No homozygous viable adults recovered | England et al., 2020 |
Variants
- Variant Type
- Delins
- Variant Location
- Chr 17: 21792075 - 21792078 (GRCz11) (1) Details
- Nucleotide change
- CTGT/GGACTCTTCGCCGACCACAGGTCATGGCGTTTAAACCTTAATTAAGCTGTTGTAGGCACCGACCGAGATTCCC
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 73 bp inserted / 4 bp deleted (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CAGCGGCTGGCTTACAGGAACGTTGCCCGCTGTGTTGGTGCTCTCAGAGGCCGAGTTCTCGTGATACAGGATGGGTACTCTCACAATCCTTTGTGCTGCTGCGTGGCTCAAGTTGGCGGCCTCCAGCTCTGCGGCCAGCTGACGTTTCCATTTGTTTCTGCGGTTCTGAAACCAGATTTTCACTTGAGTCTCTGTGAGGTGAAGGGAGGCAGCAAGGCCCGCGCGCTCCGAGCTGCTGAGGTAGCGTTTCATGTCGAAGGTGGACTCCAGCTGGAACACCTGACTCCGCGAGAACACCGTGCGAGTTTTCTTTTTCCGGCAAGGTTTCTTGTCAGCGCCGTCGTCACTCTTCTTCCAGTCGTCTATGCCGCCTTCTTTTTTACCGTCTTCGGTGTCGCTCTCCTCGAGGACAATCTCGTCGCCACTTTTGTTGTCGTCTTCATCGTCCTTGGCGTCCGGATCTGATTTGAGCACAAGCTCGGGGGAATCTCGGTCGGTGC
CTGT/GGACTCTTCGCCGACCACAGGTCATGGCGTTTAAACCTTAATTAAGCTGTTGTAGGCACCGACCGAGATTCCC GGTCGGCGAAGAGTCCCTCGCTTTCTGTGCTGCTACAGTAATAGAGGCCAAATTAGCATTCGTTTTCTTTCAGAAACATATTCATATCAAGTTTCACTGGTCGTGTCACTTTGCCACATGACAGGTGCAAACAATTGTGATTCGCACTGTCCAAAATCTCAGTGTTTTTAAAACTTCAACCCTGCATTTTAAACTAAAAACATGCGAGCTTTCATATTTAAAGAATGATAACAGCTGCTGTTATGTTTGATACTTAGCCTATATTATTTATAATCTGTCGGGAAACAAGCTATAGGCTGGCTTGCTACAGTGCATGCTTATGCACCAATATTTTATATCAGAATCACGCTATTAATTATCATAAATAATAAATCAGCGCAGATTACTCAACAAAGCAGTTATGAGATAATAAATCTTACCTTCTGTTCTGTGAAGATGCGCGGATGCACTGAGTGTGTACGGGTACCACCACGCCGAGGCACGCTCAAGGTAAGCCGGTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hmx3asu3/su3 | Homozygous | ♀+/- ♂+/- | 3 figures  from England et al., 2020 | 3 figures from England et al., 2020 | |
| hmx3asu3/su3 (AB) | Homozygous | ♀+/- ♂+/- | Fig 5 from Hartwell et al., 2019 | Fig 5 from Hartwell et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Haws, W., England, S., Grieb, G., Susana, G., Hernandez, S., Mirer, H., Lewis, K. (2023) Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3. Scientific Reports. 13:11511151
- England, S.J., Cerda, G.A., Kowalchuk, A., Sorice, T., Grieb, G., Lewis, K.E. (2020) Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 216(4):1153-1185
- Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051
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