Genomic Feature
hg54
- ID
- ZDB-ALT-170809-22
- Name
- hg54
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Sood Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 25: 8457427 - 8457434 (GRCz11) (1) Details
- Nucleotide change
- CATTCGGA/-
- Variant Notes
-
Deletion 8 bp in exon 13, cDNA: 1205delCATTCGGA,
p. P402QfsX11.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 13 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AATACTGCAAGACCCAAACCACACACACACACACACACACAGTTAATAGTATAATTTGTTTTTATTATTAAAGATAAAGATGGCTAGAATATGAGAATGATGTATGTTTTACATTAACAAAGCGTCTTGTGTCAGTGTGCTTGTTTTTAAAAAGAAATCTTCAATCAACATTCAAAATGCCTATATTACCCATAACCCTTAGGTATTTGAGTTCCTGAAGGGCGCCATCACTAAAAACTTCAAGGATGATCAGATTCAGAACAGCTCAAAGTTTCTGCAGGATCTCCTGCCGCAGTTTAGCAGCGTCTCTGACATGATTCTGGACACTGTCAAAAACAGGTCAGGTTTAACTATTTTTTAAATGTCTTTCTTTATTTGTTCTTATCATTTAGTGTGACATTATCTCTTTATCTGCAGTGTGTTCGGCTGGGATCATGTCACTCAGGGTCTGGTGCAACTTGGATTTATCCTGATGGACTCATTCGGCCCTAAACCAGGAC
CATTCGGA/- AAGGTGACAGAAGGAACGTCAAGTACGGCTAAAACACCAAACCAGCTAGCATGTAGACTTGGTGGACAAGTTCTCCTGGAGAGCTTTAAGGTAGAGTACAAGCAGTCATAAATCCATTAATCATGCTTCACATTTGGGAAATTAAATCTTTGTGTTGCTCTTTTATGCACAGATGCATGAACCAATCAGAGGCGAGATACTTGAACAAGTCTTGAACCGATTGGTTACTAAAACAGCCTCTCCTGTCACCCATTTCATTGGTTAGAAAACATATTTATGCAGATTCATGCTAGCTACCTATTGAATGTCTCATTTACGTCTATCTGCTGTGTTCTTCTTGCCGCAGACCTTCTTTCCAGCATAGTGTTGTCTGCTCCCATGATCCTCTTGGAATCTTCCTCTAAGGTCACAGAAACATTTGACCAGCTCTCTTATTTGCCTCTTAGTACAGTACAGGGGCTCCTCAAAGCGGTGCAGGTAACATTTCAACCCTCATGAAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| fancihg54/hg54 | Homozygous | ♀+/- ♂+/- | 2 figures  from Ramanagoudr-Bhojappa et al., 2018 | ||
| fancihg54/+ (AB) | Heterozygous | Unknown | |||
| fancihg54/hg54; tp53hg91/hg91 | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Shah, R.B., Kernan, J.L., van Hoogstraten, A., Ando, K., Li, Y., Belcher, A.L., Mininger, I., Bussenault, A.M., Raman, R., Ramanagoudr-Bhojappa, R., Huang, T.T., D'Andrea, A.D., Chandrasekharappa, S.C., Aggarwal, A.K., Thompson, R., Sidi, S. (2021) FANCI functions as a repair/apoptosis switch in response to DNA crosslinks. Developmental Cell. 56:2207-2222.e7
- Ramanagoudr-Bhojappa, R., Carrington, B., Ramaswami, M., Bishop, K., Robbins, G.M., Jones, M., Harper, U., Frederickson, S.C., Kimble, D.C., Sood, R., Chandrasekharappa, S.C. (2018) Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. PLoS Genetics. 14:e1007821
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