Genomic Feature
fb104
- ID
- ZDB-ALT-170710-3
- Name
- fb104
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Langenau Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 10: 33553734 - 33553746 (GRCz11) (1) Details
- Nucleotide change
- CATCGTCACGGTA/-
- Variant Notes
-
Y91A + 3rd new AA is 'Stop'
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 13 bp deleted from position 3554 to 3566 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TTCGCTGCGCTGGAAAGTTCAAGCTTGGTGAACTCTGACCTGCGAAATTGCATCACGTGAGACCAATCGAAGATTAAAACATGACCTCTCTGTACAGAAATTTAAAATGTGGACCAATCACCGGTCATTTTTAATATTCAATAAACTTGTTTAATCCTGTGTCAGTTCGACAAAATTTTGCAAGCTCAAAGTCTAGTTAGCAGTTAGCATTTCGTTTTATAACACTCATTACCTTCCAATTGTTCTGGTCAGTCCTGTAACGAACTTCGCTCTCAATGCAATTGTCGTTCTTCGTAACATTCCAGTAAAGCCACAGTTCAGCATCTTTTTTCTCCACCACAGACAGGTTGGTCGGAGGGTTAAGCTTCACTGTTTAACATCACAGTAACATATCAATCCATCCATAATACCATTATGGTTAAATCTTGAGAAAGCAAGAAACGAATGGCTTCTCATACCATATTCTTTCAGCATATGTTCCTGTTCCGTCACCAAACTGC
CATCGTCACGGTA/- CAGGCTTGTTTTCAATGTATTAAAGCGTTGTGTTCTTTCTTTGTAGGGGAGCATGCAGGCCACATTAACACCATTTGCTGTCTCATATTCAGGACAGTCTTCGATGTCAAAATATGAAAACCTAAGAGAAATCACACATCAATTGTAAGTTCCCCAATTTGATTTTTAAAAATGCTTTCTTGTTTCATTAATACATACCCGCCCTTGAGACTGTAATTGTACTGATGTTCGCTCCATGTGCAGTTCACATAGTCCAGATTTATGATGAGGCAGTTTATTTCTGAATAAAGATGAGAAAAACGGTATAGTAAATATTATACTGGGATACTTTAGAGGAGATTGTTCTACTTTTTGGAATTCCTGATTTTATGCAAATCTATTAATTTAGAGAGGTAATCCCAGAATAAAGACGTTTGGCGCTTGTCACATGTTGTTACTCTCTATGTGCAACTGAAACAAGGCTGGTTAAAGCAAACTGGCGCATGTGCGCAGAAAACCAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| il2rgafb104/fb104; rag2fb106/fb106 | Complex | 2 figures  from 2 publications | |||
| mitfaw2/w2; il2rgafb104/fb104; mpv17a9/a9 | Complex | Fig. 3 from Tang et al., 2017 | |||
| mitfaw2/w2; il2rgafb104/fb104; prkdcfb103/fb103; mpv17a9/a9 | Complex | Fig. 3 from Tang et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Yan, C., Yang, Q., Zhang, S., Millar, D.G., Alpert, E.J., Do, D., Veloso, A., Brunson, D.C., Drapkin, B.J., Stanzione, M., Scarfò, I., Moore, J.C., Iyer, S., Qin, Q., Wei, Y., McCarthy, K.M., Rawls, J.F., Dyson, N.J., Cobbold, M., Maus, M.V., Langenau, D.M. (2021) Single-cell imaging of T cell immunotherapy responses in vivo. The Journal of experimental medicine. 218(10):
- Zhang, S., Yan, C., Millar, D.G., Yang, Q., Heather, J.M., Langenbucher, A., Morton, L.T., Sepulveda, S., Alpert, E., Whelton, L.R., Zarrella, D.T., Guo, M., Minogue, E., Lawrence, M.S., Rueda, B.R., Spriggs, D.R., Lu, W., Langenau, D.M., Cobbold, M. (2021) Antibody-peptide epitope conjugates for personalized cancer therapy. Cancer research. 82(5):773-784
- Yan, C., Do, D., Yang, Q., Brunson, D.C., Rawls, J.F., Langenau, D.M. (2020) Single-cell imaging of human cancer xenografts using adult immunodeficient zebrafish. Nature Protocols. 15(9):3105-3128
- Yan, C., Brunson, D.C., Tang, Q., Do, D., Iftimia, N.A., Moore, J.C., Hayes, M.N., Welker, A.M., Garcia, E.G., Dubash, T.D., Hong, X., Drapkin, B.J., Myers, D.T., Phat, S., Volorio, A., Marvin, D.L., Ligorio, M., Dershowitz, L., McCarthy, K.M., Karabacak, M.N., Fletcher, J.A., Sgroi, D.C., Iafrate, J.A., Maheswaran, S., Dyson, N.J., Haber, D.A., Rawls, J.F., Langenau, D.M. (2019) Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Cell. 177(7):1903-1914.e14
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
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