Genomic Feature
mb4
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 72118557 - 72118563 (GRCz11) (1) Details
- Nucleotide change
- ACTTTGA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 3 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CATTTCAGATGATGAATCCACTAGAGGGTGCTGTCTGCATTTTTGTATATCTGAAATATGTTTCTTAAGGTACATTTAGTTGTACTTTTCAGAAGACGAATGCACTAGAGGGTGCCGTCTAGATTTTTGGCAATCTAAAATATGTTATAAGAGTACATTTTGTTGTGCATTTCATGTGAAGAATCCACAAGAGGGGGCTGTCTACATTTTCTATCTTTTATTAATCGATGAGGTCCCTGTAAATATCATTAGTGTGAAAAGGAAAAGGAAGTGGTTGGTGTCATACTGCCCCTAGTGTTTATTTCACATAGAAACTGCTGTCAAATTGTGTGCTGAAGCACATTTTTGCAGTTTCACTAAAACATAAGGCTGAATTTCAACCGCATTTCCAAAAAGTCCATGTTGGATGTGTGCCTACCACACCGAAGAGATGCGACACATAATCCTCTCCCACTGCTTTGCTTTTCTTAGGCCAGTAGGTGTAGAAGGTTTTCACATCC
ACTTTGA/- GCTCCTTCAGGTCCTCGGGGGTCATTCTGGAGAGATGATCCTCCAGCATATCTAGGGTGGTGAGCTGAGAGTCCGAGACCAGGCCGGTGTGTTTCTGAATGCGCCACAGGATACGAGCAACCAGACTGAAAACACAGCACATAATATATGAGAGGAATCATAGTAATGGAACAACCGAAACCATTCACCATTCCCAAAAACACACTGTAGATGAAGAGCATCTACACTCCCTGACAAAAGTGTTGCTGCTTATCCAAATTGTAGGAACAGCAATAATAACTTGCCTTCTAATCGATGATTTGGTGTCAGAAGTGTCTCTATGAAAGGTGAAGGCCTCTAGATGAGCTCAATAAATCTGATCATGTCTTGATGTTGACTGATTTGATGAGGACAGTGCGCTCTGACTCTGCTCAGACTAAAGTGTCATCACTGAACAGAAATAATGTCCAGTATAGAATATAAAGTCCTGCTGCAGTGGAGACAGAATGAATATTGTGTCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| smyd1amb4/mb4 | Homozygous | ♀+/- ♂+/- | Fig. 7 from Cai et al., 2019 | Fig. 7 from Cai et al., 2019 | |
| smyd1amb4/mb4; myom3mn0067Gt | Complex | Fig. 8 from Cai et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Cai, M., Han, L., Liu, L., He, F., Chu, W., Zhang, J., Tian, Z., Du, S. (2019) Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5):6209-6225
- Anderson, J.L., Mulligan, T.S., Shen, M.C., Wang, H., Scahill, C.M., Tan, F.J., Du, S.J., Busch-Nentwich, E.M., Farber, S.A. (2017) mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. PLoS Genetics. 13:e1007105
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