Genomic Feature
uc31
- ID
- ZDB-ALT-170117-4
- Name
- uc31
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Draper Laboratory
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 51772835 - 51772872 (GRCz11) (1) Details
- Nucleotide change
- AAATGAGGGTTTCTCCTTTTTGGGTGTCGATTTTGGTG/-
- Variant Notes
-
stop is in propeptide domain of the protein
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 38 bp deleted (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AAAAGTTTCTGAATGGTGGAAGAAGGTTGCTTAGTGATGTAAAATGTTCTTGACACCAATAACTAATCACTGAAAAGCTTTTCTGGGGACCAACATGGTTTAAGGCTTAATCACTGTTTATGGGAGGCAACCTCTGTTTTTAAGAGTGCAGATTTCATTAACAACAGTAAAGAATCTATAAAGATATATTCCCCGCATTATATTCAATAGGATGCTAACAATTGCAATAAACATTTTAGGAGTCTAGAAGAGAACTAGAAATAATCATATGATGCATAACATATGGATTAAAGGATGTAAATGAGAAATGATAGAGTGCTTTACCACTTGATGTTGGGAGAAAGTGTTTTTCAGTGGTTGATGCTTGAAGCAGTCTTATGGTGTTGGACCCAAAAATCTTGTGCTGCTTTGGTCGTCCATCTGCATCCGCCGCTATCCTGTATAGACTCAACATCAGTCGCATGCCATCATCGTCAGTTCGGCTTTCTACGGGAGGTCTA
AAATGAGGGTTTCTCCTTTTTGGGTGTCGATTTTGGTG/- AACTTCTGTACTGGCGACGCCAAAATGTGACGGGGAGGCCATGTTTCCGGCCACGCGCGTGAATATGTGCAGCACAAACAAACAGGACAGTACGCAGAGTCTCAGACCGTTGGGGCCGCTGGTAGCCTTCATGTTCAGCCCCTCGTACGCACGAGTGCCACCTGAAAGGCTACCATCGTCTAAGACAATCAGCGGGCGGAATTCAACCTGAACATCAGCTGACGGCCACAAACTTTCTGGTGCGCCTCTAATCGTGTGACGTCATGTCCAATTATCCGTCAAACGTCAAAGGCCGCATTCGTGTGGTTTATATCCGGTATGGAAATTAAGTGCACAGGAGTTTATTTCCAGAACCCACATTCAGTTTATTGTATTATTTTTCATAAGTCAGATGTACATTGCACTCTTATTTTCATTAAAACCAACTGGCCAATCAAGTATATTAATACAATTTTAATCCATAGTTTGGTAGTTAATTATGGCATATTCAGTGGGCATCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| bmp15uc31/uc31 | Homozygous | Unknown | |||
| bmp15uc31/+; uc02Tg | Complex | Fig. 2  from Dranow et al., 2016 | |||
| bmp15uc31/+; uc44Tg | Complex | Fig. 5 from Dranow et al., 2016 | |||
| bmp15uc31/uc31; uc02Tg | Complex | Fig. 2 from Dranow et al., 2016 | Fig. 2 from Dranow et al., 2016 | ||
| bmp15uc31/uc31; uc44Tg | Complex | Fig. 5 from Dranow et al., 2016 | Fig. 5 from Dranow et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Bravo, P., Liu, Y., Draper, B.W., Marlow, F.L. (2023) Macrophage activation drives ovarian failure and masculinization in zebrafish. Science advances. 9:eadg7488
- Romano, S., Kaufman, O.H., Marlow, F.L. (2020) Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2a/b. Development (Cambridge, England). 147(18):
- Dranow, D.B., Hu, K., Bird, A.M., Lawry, S.T., Adams, M.T., Sanchez, A., Amatruda, J.F., Draper, B.W. (2016) Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish. PLoS Genetics. 12:e1006323
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