Genomic Feature
vu532
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 1: 29097120 - 29097127 (GRCz11) (1) Details
- Nucleotide change
- TTCACCAC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 1 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CATTAAATACTGACGTTCTACAGCCATGTAGCTTCATCTGGTCTGGTTTGTTTTGGCAGGCACTTATTTTCCGGTGATAGTTGGCCACAAGAGTATTGTCTGAGCCATTCAGTGCTAGACTGTCATTCTCAGGTCAGAGTCCACCCCGCTGATTCTGCTGACAACACTGTTCCCACCATGAGATAATGCCATTCCAGAGAGATCCATTTGTAAGCCCCTCTTTCTGCAGCACAGGTATATAACCAGGGGTCTGCCTCCACTAAGGCCGGCACACATCATTTGGGGATCTTTGTACTGTACTAGCCTCTATTAGCCTCCTACTTGCGTTCAGTTCACATCTTTTGTTCATCAGGTGCAATAAGTTACAGTAAGGAGTTACCAGGTCTGACATTATGGATATTGCGATCCAACACCCTTGGTTCAGACGCACACTGGGCTACCCCACCCGACTCTTTGATCAGTTCTTTGGAGAAGGCCTGTTCGATTATGACCTATTCCCC
TTCACCAC/- TTCAACTGTCAGCCCTTACTATCGACACTCACTCTTCCGCAACATCCTGGACTCCTCCAACTCAGGTGTCTCTGAGGTATTGAATTACTTTATTGCTAATTGAGAGAATATTTTGATTTACTAACTTAAATGATGCTGAAAACCACTATGCGGGAGCGGGGTGAAGGTTGTGTGTGCGGGGGTCAGGGGGGATTCATATACTAAAAAAATTTAAGTAAAGGAATCCTTAAAGTTTTTCCTTCAGAAATGAAATTGAAATGAATCATAAAAATGAAGCAAGATAATGGACAAGATTCAAATTCAGACTAAATTGTACAAACTAACAAAGCTGACAGATACAGTGCTATAAACAAATATTTAGAAATTTAAGTACATTTAATCCATCTAATGACAAACTATATTGAAATTTAACCAAATCACCAGCAAGAAGTTTTGGATTTACCTCCAATTATATGCTCTAAAACTAGCTGTTTTAAAGTTGATGTCCAACGCTTTTTCTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cryaavu532/vu532 | Homozygous | ♀+/- ♂+/- | Fig. 3 from Zou et al., 2015 | ||
| cryaavu532/+ | Heterozygous | Unknown | Fig. 5 from Wu et al., 2016 | ||
| cryaavu532/+; vu531Tg | Complex | ||||
| cryaavu532/+; vu533Tg | Complex | Fig. 5 from Wu et al., 2016 | |||
| cryaavu532/+; vu615Tg | Complex | Fig. 1  from Wu et al., 2018 | |||
| cryaavu532/+; vu616Tg | Complex | Fig. 1 from Wu et al., 2018 | |||
| cryaavu532/vu532; vu615Tg | Complex | Fig. 1 from Wu et al., 2018 | |||
| cryaavu532/vu532; vu616Tg | Complex | Fig. 1 from Wu et al., 2018 | |||
| cryaavu532/vu532; cryabavu612/vu612 | Complex | Fig. 3 from Mishra et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Mishra, S., Wu, S.Y., Fuller, A.W., Wang, Z., Rose, K.L., Schey, K.L., Mchaourab, H.S. (2018) Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. The Journal of biological chemistry. 293(2):740-753
- Wu, S.Y., Zou, P., Mishra, S., Mchaourab, H.S. (2018) Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants. PLoS One. 13:e0207540
- Wu, S.Y., Zou, P., Fuller, A.W., Mishra, S., Wang, Z., Schey, K.L., Mchaourab, H.S. (2016) Expression of Cataract-linked γ-crystallin Variants in Zebrafish Reveals a Proteostasis Network that Senses Protein Stability. The Journal of biological chemistry. 291(49):25387-25397
- Zou, P., Wu, S.Y., Koteiche, H.A., Mishra, S., Levic, D.S., Knapik, E., Chen, W., Mchaourab, H.S. (2015) A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Experimental Eye Research. 138:104-13
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