Genomic Feature
hu9963
- ID
- ZDB-ALT-160721-19
- Name
- hu9963
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Schulte-Merker
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 24: 1248759 - 1248769 (GRCz11) (1) Details
- Nucleotide change
- TTGCCCACCAG/-
- Variant Notes
-
Frameshift at aa 96; 37 additional aa then stop.
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 11 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: at position 96 (1)
- Flanking Sequence
-
ACCCCTACAATGTTTTGAATTTAGACTGCAATACCGGGTTCAACCACTAGGTAGGTCTCGATAATCAGGCATGCTTGCAAAATGTTGATGTTGTCAATCTGGCAACCTGTTTGTATGTCGAGTCATCATCAGAGGGTGCCATGTGAAAAATATACACACAATGATTTGAATTTGGACTGCAATACCTAGTTTAACCACTAGCTGTAAACCCTACTCTCTGCAAGCAGGGGCGCTGTTAGGGTTAGGACAATTCTAAAGGACCATGCTGTTTTGAGTGATACTATTAGGGGCCAACAGCAGCTTCCGGCTCATGACAGACTTAAATAGGGCTCCTTGGCCTCATAAAGTGGATGTTTGTAAATGTTTTTTCCTTACCCGTTTTGAAGATCTCATAGCGGATGGAGAATCCGGCACCGTGAGTCTCGTAGTCGGACACAAACTTGATGAAGAGCTGGTTTCCCGACGAGACCACCGGAGATGGAGCGATCTTTCCACAATAT
TTGCCCACCAG/- CTGCCCGTTCTCATCCACGCCGTCTCTCACTTCCACATAGTCATATCTGCAGAGAGAGAAACACACACATGAACACACATTCATCTGAACATCTAACAATAACTAACACAATAACACTCAAAAATGTCCATAAAACAAATTGGCACTAATGTAAAGCACATTTTTAATCTGCAGTGTTTAAAATAAAGTGTAATATTTACTACTTTTGAGTACTTTTAGAAGGCCTAACTTCACTCATAATTTAAGTATTGCTTACAACAGATACTTTTACTGTACTTGCACATGCATAGTCATATCTGCAGAGAGAGAAACACACACAAACAGAACATCTAACACTGTCACAGCAGCTCAGCTGATTCAGATGAACAGTAAATGATATTTGGTTTGTTTATTTATTGCCACATAAGCAATATTTTGGCTACTTATGGCAAGATCAATATAAATAAAAATATATTACATAATAATAATAATAACAACTTCATAATACAATTGACCCTTTT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nrp1ahu9963/hu9963 | Homozygous | ♀+/- ♂+/- | text only from Kok et al., 2015 | ||
| nrp1ahu9963/hu9963; s843Tg; sd2Tg | Complex | Fig. 3  from Kok et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- de Bruin, A., Cornelissen, P.W., Kirchmaier, B.C., Mokry, M., Iich, E., Nirmala, E., Liang, K.H., Végh, A.M., Scholman, K.T., Groot Koerkamp, M.J., Holstege, F.C., Cuppen, E., Schulte-Merker, S., Bakker, W.J. (2016) Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic acids research. 44(8):3549-66
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
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