Genomic Feature
zf592
- ID
- ZDB-ALT-160127-1
- Name
- zf592
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 13: 2523711 - 2523732 (GRCz11) (1) Details
- Nucleotide change
- CGCTGTGAGCTAGTAAATGAGA/ATCAAGCT
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp inserted / 22 bp deleted in Exon 2 (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ATTTCTAAACAATAGTTTTAATAACTCATTTCGAAGTGACATTTAAAGGCTTAACTAGGTTAGTTAGGGTAAAGTTAGGGTAATTAGGCAAGCCATTGTATAACAGTGGTTTGCTCTGGAGACAATCCAAAACTAATATTGCTTAAAGGGGCTAATAATATTGAGCTTAAAATGAGTTTAAAAAAAAGCTAAAAACGGCTTTTATTCTTGCCGAAATAAAACAAATAAGACTTTCTCAAGAAGAAAAAATATTATAGGAAATACTGTGAAAATTTCCTTGCTCTGTTCAACATCATTTGGGAAATATTTAATAAAGTAAATTCACAAGAGGGCGAATAATTCAGACGTCAACTGTTTTCTTATTTGTTTATTATTGGGGCTTTGAGGTCAATTTAATTGTTGTTTCTTCATTCTCCAGGATGTTATTGGCTGGAAATGGTGTCTTCTTTCTCTTCTCTTTGTTTTTCCTGCTGGCGGCTGCTCAGAGCTTGGTTTTTCCA
CGCTGTGAGCTAGTAAATGAGA/ATCAAGCT CGGTATCGGTGGAAAAAGAGGGCTGTCCAAAATGCCTGGTGTTTCAGACCACCATCTGCAGCGGCCACTGCGTAACAAGGGTGAACACATTTGGGAAAACATTTTTTTTGTGTAGTATCACAGTCATTGTCACAGCAAGATCGCCGGTTCGAGTCCAGGCTCGGCCAGTTGGCATTTCTGTGTGGAGTTTGTATGTTCTCCCCGTGTTGGTTTCCTCCAAGTGCTCTGATTTCCCCCACTGTCACATACACATGCGCTATAGGGAATTGGATAAGCTAAATGGCCTTAGTGTATGAGTGTGTGTGTGTGTGTGTGTGTGTGAGAATGAGTGTGTATGGGTGTTTCCCAGTACTGGGTTGCGGCTGGAAGAGTAAAACTTGTTGGCAGTTCATTCTGCTGTGGTGATCCCTGATGAATAAAGGAACTAAGCCGAAGGAAATTGATTGAATGAATATTTCTTTTATGTTGTCCCAACACAAATTGATGGTGTGGGACCCAAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lhbzf592/zf592 | Homozygous | ♀+/- ♂+/- | 4 figures from Chu et al., 2014 | Fig. 10 from Chu et al., 2015 | |
| lhbzf592/zf592 | Homozygous | Unknown | Fig. 2 from Tang et al., 2016 | ||
| lhbzf592/+ | Heterozygous | Unknown | 2 figures from Chu et al., 2014 | ||
| fshbzf686/zf686; lhbzf592/zf592 | Complex | 2 figures from Chu et al., 2015 | 2 figures from Chu et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Li, J., Huang, D., Sun, X., Li, X., Cheng, C.H.K. (2018) Zinc mediates the action of androgen in acting as a downstream effector of LH on oocyte maturation in zebrafish. Biology of reproduction. 100(2):468-478
- Xie, Y., Chu, L., Liu, Y., Sham, K.W.Y., Li, J., Cheng, C.H.K. (2017) The highly overlapping actions of Lh signaling and Fsh signaling on zebrafish spermatogenesis. The Journal of endocrinology. 234(3):233-246
- Tang, H., Liu, Y., Li, J., Yin, Y., Li, G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X., Cheng, C.H. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports. 6:28545
- Chu, L., Li, J., Liu, Y., Cheng, C.H. (2015) Gonadotropin signaling in zebrafish ovary and testis development: insights from gene knockout study. Molecular endocrinology (Baltimore, Md.). 29(12):1743-58
- Chu, L., Li, J., Liu, Y., Hu, W., Cheng, C.H. (2014) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular endocrinology (Baltimore, Md.). 28(11):1785-95
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