Genomic Feature
s985
- ID
- ZDB-ALT-151020-2
- Name
- s985
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 8: 38043226 - 38043227 (GRCz11) (1) Details
- Nucleotide change
- AA/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 2 bp deleted in Exon 16 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CATTCCATAAAGTAATTTATTACACGTCTGCGTATGTATATTAGATATACTATTATCACAATTATAATTTTAAATTATTATATAAATTAATTTTCTATTATATTTATATTATAATTTTAGCAGCTATCATTTATTGATATTGTGCAGCCTTAGTAACCATACACACAAATAAACATTGTTTACATAATATACACATTTTTCTTATTTTAATTTTAATTATATTTTAATAACCTGCAACAACTCATGGCCAAACAAAGATCATGATTTATTTATTTTTTACTTTTTCTTTTTTTTTTTAACTGAAAATCTCCACAAAATCTCCTCCATCTCTGGTATGGATTTTGTTTCTGTCTCAAACCTTTGTTTATTCTCCATGAAGACCCTGAAAAGTTGTGGGAAAAGTACTTAATCGAACAAAACACTTTTTTTTGTACAAAACCAAAATAGTGACTTACTGCCTGGCATACAATTGGGTATCCTGTCAGAGTGATGCCTCCAGC
AA/- ACACTGCAGACGTCATTGCAACATGGAAACTAGTGTTCAGGAGAGTGTGCCAACTCTTCCTCGTGATTCTGATGGAGCTAATGGTAGAAAAATAAAATGTTTAAACATTTCACAGGTTTGGCTCCTCCAGTGAGTGCCAACCACCTTCTGGTAACATTTTTGGGTCCTTTAAAATACATTAACTAATATACCTCAGTGTTAGCAAATATATCTGTGACTTTTTTAATAGGTCAAACAAATACCTATGGTGCAGTATATAAGTGATGATGATGGTGAAGAGGCAGAGGAGCAGCACTGCAGTGCAAGTGTAAATCACAGGATGAAGCACTTCCACTGGAATCGAAGGTGAACCTGGGAAGTCTGGTATCTCCTTAAACATTTATGAAGAAAATGGAGAAAGCATTTTTTAAAGATTCAGTTTTTTGATTTTACAGCATGTTTACACCTCAAGGCTGTCAAAACAGAGATAAAAATAAATAAATAAATAATATATATATATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| adgra2s985/s985 | Homozygous | Unknown | Fig. 2  from America et al., 2022 | ||
| adgra2s985/s985 | Homozygous | ♀+/- ♂+/- | Fig. 1 from Vanhollebeke et al., 2015 | ||
| adgra2s985/s985; s843Tg | Complex | Fig. 1 from Vanhollebeke et al., 2015 | Fig. 1 from Vanhollebeke et al., 2015 | ||
| adgra2s985/s985; s843Tg/s843Tg | Complex | Fig. 2 from America et al., 2022 | Fig. 2 from America et al., 2022 | ||
| adgra2s985/s985; w61Tg/w61Tg | Complex | Fig. 2 from America et al., 2022 | |||
| adgra2w192/+; adgra2s985/+; s843Tg | Complex | Fig. 1 from Bostaille et al., 2017 | |||
| adgra2w192/+; adgra2s985/+; w61Tg | Complex | Fig. 1 from Bostaille et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- America, M., Bostaille, N., Eubelen, M., Martin, M., Stainier, D.Y.R., Vanhollebeke, B. (2022) An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell Reports. 39:110902
- Bostaille, N., Gauquier, A., Stainier, D.Y., Raible, D.W., Vanhollebeke, B. (2017) Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants. Development (Cambridge, England). 144(1):8-11
- Vanhollebeke, B., Stone, O.A., Bostaille, N., Cho, C., Zhou, Y., Maquet, E., Gauquier, A., Cabochette, P., Fukuhara, S., Mochizuki, N., Nathans, J., Stainier, D.Y. (2015) Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. eLIFE. 4
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