Gene

adgra2

ID
ZDB-GENE-081104-363
Name
adhesion G protein-coupled receptor A2
Symbol
adgra2 Nomenclature History
Previous Names
  • gpr124
  • si:dkey-208c22.2
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor activity. Involved in several processes, including blood vessel morphogenesis; dorsal root ganglion development; and positive regulation of canonical Wnt signaling pathway. Localizes to Wnt signalosome and plasma membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Harty et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adgra2 Human Ortholog
No data available
Associated With adgra2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000203 GPS motif
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR001879 GPCR, family 2, extracellular hormone receptor domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR017981 GPCR, family 2-like
Family IPR000832 GPCR, family 2, secretin-like
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Cysteine-rich flanking region, C-terminal GPCR, family 2, extracellular hormone receptor domain GPCR family 2, extracellular hormone receptor domain superfamily GPCR, family 2-like GPCR, family 2, secretin-like GPS motif Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype
UniProtKB:F1Q989 973
UniProtKB:E7FBY6 1367
UniProtKB:A0A2R8RYE4 1343
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations