Genomic Feature
s984
- ID
- ZDB-ALT-151020-1
- Name
- s984
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 8: 38053859 - 38053863 (GRCz11) (1) Details
- Nucleotide change
- GTGAG/AATAACGGTAATAAC
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 15 bp inserted / 5 bp deleted in Exon 7 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TAATTATTTATTTATTAAGTAGCAAAAACAATTTTCCAATATAATATGCTATTTTGTGTGGAGTTTGCATGTTCTCCCCTTGATGGCATTGGTTTGCTTCGTAAAACATATGCTGGATAAGTTGGTGTTTCATTCTGCTGTGGCACCCCTTAATAAATAAAATGATAAATTGTTGGGTTGCAGCAGGAAGGGCCTCTGCTGTGCTGCTCGATTAGTTGGTGGTTCATTTAGCGTTGGTGACTCCTGATGATTAAAAGAGACTAAGCTGAAAAGAAAATGAATTAATGTATATTACCAAACTGTTTCAATTCAATATAGTATGTGTTACCTTGTGATGAAGGTACAGTCATGTTGTACACTCTCCTCCAGATGAATTCCCTTGGTAGGGTCACTGGTAACAGGCTGACCATTTTGTCGCCAGTGAAGGGCAGTAATTTTGTCAACCAAAGAGGCAGTGCAATGGAAAGGCAGCCTGTCTCCCTTAAAAACAACCTGCCGCT
GTGAG/AATAACGGTAATAAC GGTAATAACGACAATGTGTGCAGTTCCAGTGGACCCTCTGAAAAGCAAAATTAATTGAAATATAAACATGAGAATCACAGAAAAAAAAAATATTACAAAGTCATGGCTTGTCTGCAGTTCCAACCTGTCTCCAATAAAGAATCTGTAGTGCATTTTGAAGTGCGATTTTCAGTTTCTCATATTCGTCAGCAGTTCAGCCTCAAATTGACACAGGTAATAAAAAAAATCTACTTAGCCATGTTCATCAAAATGTCCACTTTTGATTATATAAGACTTGTTTTCAATAGCGATTTTAAAACTTTTAATATAGGCTATTATAAATCAGAAAATGAGTGTACATAGTTTTACGTTAGGAAATGCAGTCTTAAATTTACAAACAGTCGGCAAGTACTAGAGAACGGATGTACACGCTCATGTCAAAGTAAAGCTCAACTTGCTTTGTTTTGCCTTCATTCATTTTTGTTTTCAGTAGTGACATAAAACACAAGTTTTTAAACACA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| adgra2s984/s984 | Homozygous | Unknown | 4 figures  from 3 publications | ||
| adgra2s984/s984 | Homozygous | ♀+/- ♂+/- | 2 figures from Vanhollebeke et al., 2015 | ||
| adgra2s984/s984; ia4Tg; s896Tg | Complex | Fig. 1 from Bostaille et al., 2017 | |||
| adgra2s984/s984; is4Tg; s982Tg | Complex | Fig. 6 from Vanhollebeke et al., 2015 | Fig. 6 from Vanhollebeke et al., 2015 | ||
| adgra2s984/s984; la207Tg | Complex | Fig. 1 from Rasmussen et al., 2018 | Fig. 1 from Rasmussen et al., 2018 | ||
| adgra2s984/s984; mu240Tg | Complex | Fig. S8 from Hübner et al., 2018 | |||
| adgra2s984/s984; s843Tg | Complex | 3 figures from 2 publications | 2 figures from Vanhollebeke et al., 2015 | ||
| adgra2s984/s984; s843Tg/s843Tg | Complex | Fig. 2 from America et al., 2022 | Fig. 2 from America et al., 2022 | ||
| adgra2s984/s984; s896Tg; ubs1Tg | Complex | Fig. 6 from Vanhollebeke et al., 2015 | Fig. 6 from Vanhollebeke et al., 2015 | ||
| adgra2s984/s984; s1010Tg; s896Tg | Complex | Fig. 6 from Vanhollebeke et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- America, M., Bostaille, N., Eubelen, M., Martin, M., Stainier, D.Y.R., Vanhollebeke, B. (2022) An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell Reports. 39:110902
- Bump, R.G., Goo, C.E.A., Horton, E.C., Rasmussen, J.P. (2022) Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis. Development (Cambridge, England). 149(3):
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Jensen, L.D., Hot, B., Ramsköld, D., Germano, R.F.V., Yokota, C., Giatrellis, S., Lauschke, V.M., Hubmacher, D., Li, M.X., Hupe, M., Arnold, T.D., Sandberg, R., Frisén, J., Trusohamn, M., Martowicz, A., Wisniewska-Kruk, J., Nyqvist, D., Adams, R.H., Apte, S.S., Vanhollebeke, B., Stenman, J.M., Kele, J. (2019) Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1432-1447
- Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
- Hübner, K., Cabochette, P., Diéguez-Hurtado, R., Wiesner, C., Wakayama, Y., Grassme, K.S., Hubert, M., Guenther, S., Belting, H.G., Affolter, M., Adams, R.H., Vanhollebeke, B., Herzog, W. (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nature communications. 9:4860
- Rasmussen, J.P., Vo, N.T., Sagasti, A. (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Developmental Cell. 46(3):344-359.e4
- Bostaille, N., Gauquier, A., Stainier, D.Y., Raible, D.W., Vanhollebeke, B. (2017) Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants. Development (Cambridge, England). 144(1):8-11
- Bostaille, N., Gauquier, A., Twyffels, L., Vanhollebeke, B. (2016) Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking. Biology Open. 5:1874-1881
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