Genomic Feature
uwm25
- ID
- ZDB-ALT-151016-1
- Name
- uwm25
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Huttenlocher Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 1: 14253484 - 14253489 (GRCz11) (1) Details
- Nucleotide change
- TCGCTG/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 6 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- Amino Acid Deletion: 2 AA missing (1)
- Flanking Sequence
-
GCTTCCAAAATTCCTGAAACTAATTAATCTTGCTGTCACATCAAGTCACATGACTGAGGGTGATCTGAGATTCACTTGTGACATCAGGAAAAACTTTCCCAAAGAGGGATATTGCGCAACTCCCTCTGACTCATATCCAGGATACAGCTACAGTATATAAGCGCTACGGCTTCAACATGTTGACAGAATTCACCAGCTGAACTGAGCTCCTCAGGAATCTACAATCCAAGCTCTAGATTTGCTTTTAATTTCTTTCGTCTTGATATTATTAGACTCACTTAGGCAAAATGACCAGCAAAATCATTTCAGTGTGTGTTATTGTTTTCCTGGCATTTCTGACCATCATTGAAGGTAAGTGAACATGCAAAACCATATACTGCTATAACTATCAGTAACCATAGATAGTTATGCATATATGTGGTAGAATGATATGAACTAATCCCTGTGATTTTTTTGCTTTCAGGAATGAGCTTGAGAGGTCTGGCTGTAGATCCACGCTG
TCGCTG/- CATTGAAACAGAAAGCCGACGCATTGGAAAACACATAAAGAGTGTGGAGCTCTTCCCTCCAAGCCCACACTGTAAAGATTTAGAGATCATGTGAGTTTTCAAACTAATACGGCAGTAATACAAGGATTTAATGAATCCATTATGATCTAGATGGATGCAAATTTAGGTTTCTTACTGATTTTCTTCTAATGTTTTTCCACAGTGCCACCTTGATGACAACTGGACAGGAGATCTGTCTGGACCCCTCTGCTCCATGGGTTAAGAAGATCATTGATAGGATCATTGTCAAGTAAGCATAAATAAATTTTGGGTTAATTTTTAAACACTTCGTATAAAAGTGATCCAGTTTTGTAAAAGTTATCATGCAAACCTTCTAAAAAAATGATTTTTTTTTGCAGCAGAAAACCATGAATGCCCGGATCACCTGTGAAGTCAAGTTTGATGATGTTCATACGTCAGACATTTCATTTTGTACCAATGGATACATTTTTATAAATATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cxcl8auwm25/uwm25 | Homozygous | ♀+/- ♂+/- | Fig. 5  from Cortes et al., 2016 | Fig. 7 from Jing et al., 2015 | |
| cxcl8auwm25/+ (AB) | Heterozygous | Unknown | |||
| cxcl8auwm25/uwm25; cz2010Tg | Complex | Fig. 2 from Blaser et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Blaser, B.W., Moore, J.L., Hagedorn, E.J., Li, B., Riquelme, R., Lichtig, A., Yang, S., Zhou, Y., Tamplin, O.J., Binder, V., Zon, L.I. (2017) CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. The Journal of experimental medicine. 214(4):1011
- Powell, D., Tauzin, S., Hind, L.E., Deng, Q., Beebe, D.J., Huttenlocher, A. (2017) Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 19:1572-1585
- Cortes, M., Chen, M.J., Stachura, D.L., Liu, S.Y., Kwan, W., Wright, F., Vo, L.T., Theodore, L.N., Esain, V., Frost, I.M., Schlaeger, T.M., Goessling, W., Daley, G.Q., North, T.E. (2016) Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Reports. 17:458-468
- Jing, L., Tamplin, O.J., Chen, M.J., Deng, Q., Patterson, S., Kim, P.G., Durand, E.M., McNeil, A., Green, J.M., Matsuura, S., Ablain, J., Brandt, M.K., Schlaeger, T.M., Huttenlocher, A., Daley, G.Q., Ravid, K., Zon, L.I. (2015) Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. The Journal of experimental medicine. 212(5):649-63
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