Genomic Feature
p181
- ID
- ZDB-ALT-150701-11
- Name
- p181
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Michael Granato Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 25: 19956347 (GRCz11) (1) Details
- Nucleotide change
- C/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>A at position 750 in Exon 1 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Asn>Lys at position 250 (1)
- Flanking Sequence
-
CCGAGCTTTGATGCCATCCTGTACTATTATCAGTCCGGCGGACGACTGAGAAGGCCGGCGAATGTCCCGTTGGATATGTTCTCAGAAGAAATTAAGTTCTATGAACTTGGGGTGGAGGCAATGGAGAAGTTTCGTGAGGATGAGGGCTTTATCCGTGAGGAGGAGCGACCTTTACCAGAGAAAGAGTTTCAGCGACAAATCTGGCTCCTGTTTGAGCATCCTGAGAGCTCAGGGCCAGCCAGAGGAATTGCTATTGTGTCTGTTATGGTCATTTTAATTTCCATCGTCATTTTCTGTTTGGAGACTTTACCTGAACTGAAAGAGGACCCTGAGGGGCGTATAAAGATTATAGGCAACACCACATACTACTACAAACCTAGCATTCTGGCCGATCCATTCTTCATCATTGAGACCCTCTGCATTATCTGGTTTTCATTCGAATTGATAGTGCGCTTCTTTGCTTGCCCAAGCAAAGCGGCCTTCTTTAAGAACATGATGAA
C/A ACCATTGACATTGTGGCTATTATCCCTTACTTCATCACGCTGGGCACAGAGTTAGCAGAGGAACAAGACGGAAAAGAGGGAAAGGGCGAGCAGGCAACATCACTGGCCATCCTCAGGGTGATCCGTCTGGTCAGGGTGTTCAGAATCTTCAAGCTGTCCAGGCACTCCAAAGGCCTTCAGATTTTAGGGCAGACCCTCAAAGCCAGTATGCGAGAGCTCGGATTGCTTATTTTCTTCCTCTTCATTGGCGTCATATTGTTCTCCAGTGCTGTGTATTTTGCAGAAGCAGAGGAAAAGGAGTCCTACTTCAGCAGCATCCCAGATGCATTCTGGTGGGCAGTTGTGTCAATGACTACCGTAGGCTACGGGGACATGGTCCCAGTGACCATCGGGGGCAAGATTGTGGGTTCCCTGTGCGCCATCGCTGGTGTGCTGACCATTGCCCTCCCCGTGCCAGTCATTGTGTCCAACTTCAACTATTTCTATCATAGAGAAACCGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kcna1ap181/p181 | Homozygous | ♀+/- ♂+/- | 5 figures  from 3 publications | ||
| kcna1ap181/+ | Heterozygous | ♀+/- ♂+/- | Fig. 4 from Nelson et al., 2020 | ||
| kcna1ap181/p181; nkhspGFF62ATg; y362Tg; zf206Et | Complex | Fig 5 from Meserve et al., 2021 | Fig 5 from Meserve et al., 2021 | ||
| kcna1ap181/+; kcna1ap410/+ | Complex | 2 figures from 2 publications | |||
| kcna1ap181/p181; prdm12bp419/p419 | Complex | Fig 7 from Meserve et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Meserve, J.H., Nelson, J.C., Marsden, K.C., Hsu, J., Echeverry, F.A., Jain, R.A., Wolman, M.A., Pereda, A.E., Granato, M. (2021) A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1. PLoS Genetics. 17:e1008943
- Nelson, J.C., Witze, E., Ma, Z., Ciocco, F., Frerotte, A., Randlett, O., Foskett, J.K., Granato, M. (2020) Acute Regulation of Habituation Learning via Posttranslational Palmitoylation. Current biology : CB. 30(14):2729-2738.e4
- Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. (2015) A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning. Neuron. 85(6):1200-11
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