Genomic Feature
um197
- ID
- ZDB-ALT-140917-10
- Name
- um197
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Sagerström Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 12: 27141724 - 27141740 (GRCz11) (1) Details
- Nucleotide change
- CAGCCCTTCCACCTCAA/TGTTTCAATCGTGAAACACAAATTCACAAATTCAAT
- Variant Notes
-
Weicksel et al, 2014: Insertion/deletion (+19 bp)in exon1 of hoxb1b
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 36 bp inserted / 17 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TAATTCACATTAGACCTACATAGCGACTTTATCAGATTGACGGGTGGATTCGATTGATGTGTTTGTCATGTAAATACGAATCGTTTGATGGACACCTGCAACGCCCAGAGTGCTACCGCAGGTCGCACACTATTGGCGCAAAATTAGTCACATGATCTGTCACTTAACTGATATGAGCTCAGATACAACTTTGCGTGGTTTGACATACTGCTTAGAGGTTGTAGGGGCACTGGGACCACACATCAGCTCATATTGACCCTGCTTAATCAATTTTGCTTGGTCAGTCAACAATGAATTCTTACTTAGATTATACGATTTATAACCGTGGTTCTAACACTTATAGTTCGAAAGTTGGGTGTTTTCCTGTAGAGCAAGAATACTTGCCAAGTGCTTGTGCAAGTACAAATAGTTACATTCCCGAGGGACGGCCAGTCGGAGGAAACACTTTCACATCGGCACCGCACGAAACTCATGGCACATCTTACGCACAAATTCAATCG
CAGCCCTTCCACCTCAA/TGTTTCAATCGTGAAACACAAATTCACAAATTCAAT CGTGGACATGGGTAAAACAGGACACAGCAATTTCTGCAAGCAAACCAGACCTCCTCATTCGGACTATGGACATCAACACGTTCTCACTCAAGCAGATGACCACATGCGCCTTCAGTCCCCTGGCTTTTCCGTCGTGAATATGGGAGCCAATATTGGAACTTACAGTGAATCAAACTGCAGGCCTGGCTCGGTCTCTGCAAGCCACTATCAATCATATGCATATGGAGAACCCGAACCACACGGCTATGGTTCGTTCAGCAAGTATCAGGTCTCCCCTGACAGTGACAGCGACTCCAAGACGAACATTAAACAAGCGCCAACCTTTGACTGGATGAAAGTCAAGAGGAATCCCCCTAAAACAGGTGAGTTATGACTAGTTACAATGGCTATAGATAATGTGATATTAAAATACAGTTTCTAAGTCGTGTTTTTATTCAATGCTAATTTTCAGTTAAAGTCGCCGAATACGGAATCCATGGCCAGCAGAACATAATACGCAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| hoxb1bum197/um197 | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | 6 figures from 2 publications | |
| hoxb1aum193/+; hoxb1aum194/+; hoxb1bum197/um197 | Complex | 2 figures from Weicksel et al., 2014 | Fig. 2 from Weicksel et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Weicksel, S.E., Gupta, A., Zannino, D.A., Wolfe, S.A., Sagerström, C.G. (2014) Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish. BMC Developmental Biology. 14:25
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