Genomic Feature
sm471
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 5: 20460856 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A in Exon 6 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Amino Acid Substitution: Tyr>Stop at position 278 (1)
- Flanking Sequence
-
TGATTGTTGCCTGTAGTTTCTTTATACGTATCTGAAAGCCAATCAGAATAGGTGCTGTCAGGTAGACCTGAGCACTGCCAGACGCTGTAACACAGGCTGGGGACAGGGGAGCCTGCAGATAGCCAGATGGTCTGGTTTTGTGAGCAGGTTTGTTTTTTTTTGCTGGCTGTTTTTGGCACCGGAGTTGCGGAGGAGAACACTCTGATCACATCCCACTCAGCTAACAGAGCCAGATCACAGTTTAGGCTTTCGTACCACACAGCTCATGTTTCTGTAGCCTTTCTTCTTGGTCAGAAAATTGACGCCTTGTGATGACACTAATAAACAGAGAAGGTTTTAAAAGGTTGAACGATTGCTCATCTCCACTTGTTCATTTTGTGTTTTGTAGATATGGAGGGTACATACGCAGAGTATTCAGACTGGGCAGATGATGGCGTACCAGAGACAGTCACACACCAGTACAGACGTGCCCTGCAACAGATGGAGAAAGGCAAACCGTA
T/A GAGGAGGCCTTGGTAAATGCACTCTTGTCTCACTGCAATAGAGATCATCTGGTATTTCTAAATTGAGATTTCCATTATTATTTAATGTAAAACTGTCTCTGGGAGCAGATGCGGTGGTTATGATTTAAAAATATTTTATTCTCAGCCAAAAGCAGTCCTCGCGAGTGTCGTTACGAGAATATCCTTGAATAAAACATCTGTGGTAATGAAAGCTTTTTGTCCACAAACACCTGCTGTTCTTTTACTCGTTTAGATGTCAGCTTGACATTTCAGTTAATTTAATCTTGTCATAAGTTACATTCTTATTACTCATTCTAGGCGTGTTTTCTTGTTATGCTTTTCTTTTGTAGTTTAAGCATTAAAGAATCCACTGAATCCACATCCTTTGTGGCTGACATCACTAAGACTGCTTAACAAATTGGTGCTGGTGGTTGTTCTGCACAGTTGCCTTTAAACTTTACAATTTAACTGCTTCCTGATGGACCAAAATCAAGTCCTTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sart3sm471/sm471 | Homozygous | ♀+/- ♂+/- | 3 figures  from Zhao et al., 2021 | 5 figures from Zhao et al., 2021 | |
| sart3sm471/sm471; la2Tg | Complex | Fig. 3 from Zhao et al., 2021 | Fig. 4 from Zhao et al., 2021 | ||
| sart3sm471/+; sart3szy4/+ | Complex | Fig. 2 from Zhao et al., 2021 | Fig. 2 from Zhao et al., 2021 | ||
| sart3sm471/sm471; la2Tg + MO4-tp53 | Complex | Fig. 4 from Zhao et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Zhao, Y., Wu, M., Li, J., Meng, P., Chen, J., Huang, Z., Xu, J., Wen, Z., Zhang, W., Zhang, Y. (2021) The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Cell Death & Disease. 12:906
- Wang, K., Huang, Z., Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y., and Zhang, W. (2012) Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):473-480
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