Genomic Feature
ct817
- ID
- ZDB-ALT-131122-14
- Name
- ct817
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Prober Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 18: 16996794 - 16996795 (GRCz11) (1) Details
- Nucleotide change
- GG/CCCCCA
- Variant Notes
-
4bp insertion
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 6 bp inserted / 2 bp deleted in Exon 6 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AAGAGCAGTGTGGTAGTAAAAGAAATCTAATTCAGAGTGTCAATTTCTAAGTGTAAATATATAGTTGTTTTGCCTTTAAATATCATACAGGCTTAAAATCAAGAATCAGCCTACTCAGAGTTGACTAAACTAACTCTGTTCATGTGATCTGAAATTGAAAACTCAGATTTTTTATATCTAATAGTGAGTCAATGCAGAGTTCAAGTTTAAACCTCTTTACTAAAATGGGCCCCAGGTGTAAATGAGTATTAGTAACCCATTAGGATTAGTAGAATAAGTTGGCATGCTTGGATAATCTTAGTAATTCTGTTGAGAGACCGTGCAAAGAAAGTGTTAGCAGATACTAATCATGCAGTCCGTTAATACTCTACTGCTCGACTGGTAGGTTATTTATTGTCAACAGAATGTCAAAAGGGAACAACAAGTGCTACCAAATGCAGATGAATTCGATCATTTCACATGTTTTACCTCTTAAGAATAGAGACACGTCCTCCAGCTGT
GG/CCCCCA GATGTTGTCCTCTCTGTACCCACAATGCTTTGTCAGCAGAGGAAGGTTTTTTAAGTATTCGCGGCAGGCATGAGTTGGATAGAGTTTTGTAAGTTCTCTGTAAACGACTCCCCATGTCTTTACTTCCTCTGCAGTGTACTCAATCCGTGGGATGGGCTGCCCACTGTAACAAAGAAATTCTGATTAATTTTAAGCAGGAAGTGGGGAAAAAAAGGCAGCAACTGTCATATGCAATATCCATTGCAATAAACATCAACCTTTACCCATTTTAGCACCATTTTCTAACAATTGAGCTACAAGCACCCACCGGCACAGTCATCAACAGCAGAATTTAAACGATAGTATAATCTATACTTGCAATTTGTAGTTCATTGCAACCTCCACAAAGTACTTTCTCCTCTGCCGATAGACCTTGTCTTTAAAGCCCTGCAAAAGAGAACAAAGATTCACTTTCACAAGTTATTGTTAATAACTACATGGCGTATCTTAATGAGCAGCAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tph2ct817/ct817 | Homozygous | ♀+/- ♂+/- | 3 figures  from Oikonomou et al., 2019 | ||
| tph2ct817/ct817; ct865Tg | Complex | Fig. 4 from Oikonomou et al., 2019 | |||
| aanat2ct801/ct801; tph2ct817/ct817 | Complex | Fig. S3 from Oikonomou et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Lee, D.A., Oikonomou, G., Cammidge, T., Andreev, A., Hong, Y., Hurley, H., Prober, D.A. (2020) Neuropeptide VF neurons promote sleep via the serotonergic raphe. eLIFE. 9:
- Oikonomou, G., Altermatt, M., Zhang, R.W., Coughlin, G.M., Montz, C., Gradinaru, V., Prober, D.A. (2019) The Serotonergic Raphe Promote Sleep in Zebrafish and Mice. Neuron. 103(4):686-701.e8
- Chen, S., Oikonomou, G., Chiu, C.N., Niles, B.J., Liu, J., Lee, D.A., Antoshechkin, I., and Prober, D.A. (2013) A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly. Nucleic acids research. 41(4):2769-2778
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