Genomic Feature
t34230
- ID
- ZDB-ALT-121128-5
- Name
- t34230
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 53412838 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T in Exon 8 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Arg>Stop at position 291 (1)
- Flanking Sequence
-
TATTTTAGCTTTTTATAAATATTAAAATATTTGGAAAGTTTAAGAGTTTTTGGTTAACACACTGTGACTCTTCGATAGGTGGAGTTTTCGGCAGAGCCTCATGGGTAATGTAGTTTTTCCACTGCATGAATTTGTTTTATAATAGGCTGATTTTACGTTAACAGATGGTTCAGCAAAATCACATGCAATCGATTAACATACTCAAAACACACAAGAAGTCTGTTTATTGGTCAATCGGTAAATGTTAAAAATCACTGTCCCTATAAAAGAACATTACTGGAGATTTTACTTAGAGAATCACATTGCTGCTTTTTATGGCAAGTAAATAAATCATAAGTCTTGCACATTCACACAAAATTTTCAAAACACATTCACTTGCACTCACTTGCACTCGTAGGTTTTAGGGAAAAATGGGTGTTCGTGAGGTTTCTGGGCATCCCAACGCTGACAAGGGATTCCAGAGGTTGTTTCGTTGACTTTGCCCCTGTAATCCTCGCCTC
G/A CCCCCGAAAGCAGTTAGTGGTGTAGCTGGAGCGAAGACGACGCTTGGGAAATTCAGCTGCAGGACACAAATAAGAGTTTCTTATAAAAAAAGCCAAATTGACAATCCACAATTCTTCAAGGAATTTTATATGCAGTATTTATTATAAATATTTTGGTGTTTACTGGTGTGAGGGCTGGATCAAACTGTCACTCAAATAAAATCACTTACAGTAAACCTCAATCATCCAACCAATTTCTCATGGAAATAATCAAGCCCCACCCAAAATTTGTTGTTCTTTTCTCTGTTTGGTGTTTACTGGTTTAAGGACGGGACCAACCTGTCACTCAAATAAAATACACCATTAGAAAAGCACAAACATCCAATCAATTTCTAAAGGACATCATCAAGCCCCGCCCAACATTTGTTGTTCTTTTCTCTGATTGGTGTTTACTGGTGTGAGGGCAGGATCAAACGGTCACACTTAATATTTCCATCAAACAGTAAACCACAACTATCCAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mst1t34230/t34230 | Homozygous | ♀+/- ♂+/- | 4 figures from 2 publications | 6 figures from 2 publications | |
| mst1t34230/t34230; hu4008Tg | Complex | 2 figures from Huitema et al., 2012 | |||
| mst1t34230/t34230; zf132Tg | Complex | Fig. 2 from Huitema et al., 2012 | |||
| mst1t34230/t34230 + MO2-mst1rb | Complex | Fig. S2 from Huitema et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Witte, M., Huitema, L.F., Nieuwenhuis, E.E., Brugman, S. (2014) Deficiency in Macrophage-Stimulating Protein Results in Spontaneous Intestinal Inflammation and Increased Susceptibility Toward Epithelial Damage in Zebrafish. Zebrafish. 11(6):542-50
- Huitema, L.F., Renn, J., Logister, I., Gray, J.K., Waltz, S.E., Flik, G., and Schulte-Merker, S. (2012) Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(10):4092-4101
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