Genomic Feature
i263
- ID
- ZDB-ALT-120120-2
- Name
- i263
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Ingham Singapore Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 17: 11254089 - 11254090 (GRCz11) (1) Details
- Nucleotide change
- -/ATGG
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp inserted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
CACTGCATTAAATTCCATTGTTCTGCGTCATGTTGTTAAAATATGGAAATTTATTTTATCAATCACTGTATTTTCAATGGACTTTCTGCACTCCCTTGCAGCTCCTGACAGTGCTTTTTTCATCTCGTTTTACACTTGAATAACTAAATTAATGCTTAAGTCTATTTAACGGATTATATTAAATAACACTACAACATCGATGCTGTAAAAGCAACCTTTAAAAATGGAAAACAGTCACATTAACCCTTCACCGAATGTTTATAGGTGGCTGAAAAACACTAGCTGTGCACAAACCCCTTTAGAAACACAATGGATTGAATTTGACAATAAAAGTAGTGCCCCTTTAATATGTTTTTGTGCAAGTACCTGTTTTTTGACAGTGCTTCTAACTGCGTGTGAAGCACCTCTCCATCTTTGGCTCTCAAAATGGCTTCTAGGTTTTCTTCCAGAGTCTTCTTGCTCTGCCTGACCTGCCTCAGGACCAGTCCTGCATCCTCAAAC
-/ATGG ATGGACGTGGGCGGCTGGATGCTCTTCAGAACGCTGGCTCTGTTTAAAGCAGCAGCCCTGACGGCAATCACATCAACAGGCTCTGGGGGCTGCGAGAGTGGAGGAGAGATTGAGAGATATTGGATGCATTTAAATGACTGTATATATTTTGAGGGGGGGAAAAAACAAACTGTCTTTGTAAGAGAGTCGCTCCAGAGAATAAATATGATAAATATGTTTAATGGAATGCTGCTATGAGCCATTAGAATGAGCACAGGCATTTGGAAGCATTGTTTCCGAATGTTTTTCTGCTGACATGCCAGGAGTTGAGGAGTTTAATTTCCTCTGCCAATATTTTTTTTCACCATTCTCACTCTAAAAACTTTGTATGATTATTAAACATAACATTTTATAATTTTTATTAGCTGATGGATTATATATAATAATATAAATTACATATCACTATAATTATTTAAATGTAAACACTTTAATATATACATATTAGATTTTTAAAAATTATGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| si:ch211-185a18.2i263/i263 | Homozygous | ♀+/- ♂+/- | 4 figures  from Naharros et al., 2018 | Fig. 1 from Naharros et al., 2018 | |
| si:ch211-185a18.2i263/+ | Heterozygous | ♀+/- ♂+/- |
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Supplemental Information
- Genotyping protocol
- None
- Naharros, I.O., Cristian, F.B., Zang, J., Gesemann, M., Ingham, P.W., Neuhauss, S.C.F., Bachmann-Gagescu, R. (2018) The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance. Scientific Reports. 8:2211
- Ben, J., Elworthy, S., Ng, A.S., van Eeden, F., and Ingham, P.W. (2011) Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (Cambridge, England). 138(22):4969-4978
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