Genomic Feature
mw1
- ID
- ZDB-ALT-110211-1
- Name
- mw1
- Synonyms
-
- bugeye (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Link Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
(
order this
)
European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 48455913 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
GTTTGGACTGTGGGGGAAACCGGAGCACCTGGAGGAAACCCACGCCAACATGGAGAGAACATGCAAACTCCACACAGAAACACCAACTTGCTCAGTCGGGACTCAAATCAGCGTCCTTCTTGCCTTTAGGCGACAGTGCTAACCACTGAGCCACCCTGCCACCCAGCTCTTTATATTCATTCATTTTCTTTTCGGCTTAGTCCCTTTATTAATCAGGGGTCACCAATGTGGAATGAACCGCCAAATTATCCAGCATATGTTTTATGCCCTTCCAGCTGCAACCTATTACTGGAAAACACCCATACACACTCATTCACACACATACACTACGACCAATTTTGCTTACCCAATTCAGCTCTGTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATTTGTGTAGAACATGTCATCAGATTATCGTTATTTTCTGTCTAGGTTCAGGTTG
T/A GAGTCGGGATTTTTCCGTTGCGGGACGGGCCGGTGTATTCCAGTCAGTCAGAGATGCGATGGGACAAACGACTGTTCGGATAACTCAGATGAAATTGGCTGCCGTATGTATCAATCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCTTTTCCTTTCTTTTCTTCACAGTTTCTTACAACAAGGGCACACTGGATACTGCATGCCAGGGGCACAATTGCACATTTACTGAGGATTATGTGGGTTCAAGTTTTTTTTTCATTTTTTATTTTGCGCTCCACGTCTCTTGATTTTTCTTTCTATTTTGAACATGTAACTGTAACCGATCAACGAAATAATATCCAGGTGCAACAGATCAAATGGTCAGCGGAGGGGGAGGGGTGGTATAATTTTATATTTAATAAAATACAATAATATATCCATATAAAATGCAAAATAAACATTTTCGACAAAAATTATTTATTTCTTTTTAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lrp2amw1/mw1 | Homozygous | ♀-/- ♂-/- | 9 figures  from 2 publications | 4 figures from Kur et al., 2011 | |
| lrp2amw1/mw1 | Homozygous | ♀+/- ♂+/- | 15 figures from 6 publications | 4 figures from 2 publications | |
| lrp2amw1/mw1 (AB) | Homozygous | Unknown | Fig. 5 from Williams et al., 2022 | ||
| lrp2amw1/+ (AB) | Heterozygous | ♀+/- ♂+/- | |||
| lrp2amw1/mw1; mil1Tg/+ | Complex | Fig. 8 from Veth et al., 2011 | Fig. 8 from Veth et al., 2011 | ||
| lrp2amw1/+; mil1Tg/+ | Complex | Fig. 8 from Veth et al., 2011 | |||
| lrp2amw1/mw1 + MO1-lrp2b | Complex | Fig. S5 from Kur et al., 2011 | |||
| lrp2amw1/mw1 + MO2-lrp2b | Complex | Fig. S5 from Kur et al., 2011 |
1 - 8 of 8
Show
Supplemental Information
- Genotyping protocol
- None
- Williams, D.M., Gungordu, L., Jackson-Crawford, A., Lowe, M. (2022) Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium. Journal of Cell Science. 135(18)
- Quint, W.H., Tadema, K.C.D., de Vrieze, E., Lukowicz, R.M., Broekman, S., Winkelman, B.H.J., Hoevenaars, M., de Gruiter, H.M., van Wijk, E., Schaeffel, F., Meester-Smoor, M., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2021) Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Communications biology. 4:676
- Collery, R.F., Link, B.A. (2019) Precise Short Sequence Insertion in Zebrafish Using a CRISPR/Cas9 Approach to Generate a Constitutively Soluble Lrp2 Protein. Frontiers in cell and developmental biology. 7:167
- Park, J., Levic, D.S., Sumigray, K.D., Bagwell, J., Eroglu, O., Block, C.L., Eroglu, C., Barry, R., Lickwar, C.R., Rawls, J.F., Watts, S.A., Lechler, T., Bagnat, M. (2019) Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Developmental Cell. 51(1):7-20.e6
- Collery, R.F., Veth, K.N., Dubis, A.M., Carroll, J., Link, B.A. (2014) Rapid, Accurate, and Non-Invasive Measurement of Zebrafish Axial Length and Other Eye Dimensions Using SD-OCT Allows Longitudinal Analysis of Myopia and Emmetropization. PLoS One. 9:e110699
- McMahon, G.M., Olden, M., Garnaas, M., Yang, Q., Liu, X., Hwang, S.J., Larson, M.G., CKDGen Consortium, Goessling, W., Fox, C.S. (2014) Sequencing of LRP2 Reveals Multiple Rare Variants Associated with Urinary Trefoil Factor-3. Journal of the American Society of Nephrology : JASN. 25(12):2896-905
- Salbreux, G., Barthel, L.K., Raymond, P.A., and Lubensky, D.K. (2012) Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina. PLoS Computational Biology. 8(8):e1002618
- Kur, E., Christa, A., Veth, K.N., Gajera, C.R., Andrade-Navarro, M.A., Zhang, J., Willer, J.R., Gregg, R.G., Abdelilah-Seyfried, S., Bachmann, S., Link, B.A., Hammes, A., and Willnow, T.E. (2011) Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(6):1567-1577
- Sherpa, T., Hunter, S.S., Frey, R.A., Robison, B.D., and Stenkamp, D.L. (2011) Retinal proliferation response in the buphthalmic zebrafish, bugeye. Experimental Eye Research. 93(4):424-36
- Stujenske, J.M., Dowling, J.E., and Emran, F. (2011) The Bugeye Mutant Zebrafish Exhibits Visual Deficits that Arise with the Onset of an Enlarged Eye Phenotype. Investigative ophthalmology & visual science. 52(7):4200-4207
1 - 10 of 11
Show