Genomic Feature
ko095
- ID
- ZDB-ALT-090709-1
- Name
- ko095
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Kawahara Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 34039851 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop (1)
- Flanking Sequence
-
TCAAACAAACATTTTAATATCGCTTTACCCGGACTTTAAATATTGAATTAAGTTGATTTTCATTACAGTTAGACCTTAGCACAAAGTCAAAATGACTCTGTTATGAATCCCACAACCTCTCTTTCCAGATTGAGCAGTTTGTGTACGCCTCTCCTCATGATGGCAAATCCTGGGAGATGTTTGATGAAATGATTGGAACCGCTGAATCCTTTTATCAAACATTAGGAATTCCTTATCGAATTGTCAACATCGTGTCAGGTTTGTTCACATTCTCCTTTTTCCCTGATTTAGAGCACCAATGCAACTAAAAATTGACTTTTTTTTGGAAAACATTGAACATTTTTCTGACCGCTCCATAAAAAACGTAAAAAATTATTGTTTTCTTTTACATCACAGGTGCTTTGAACCACGCAGCTAGTAAAAAGCTGGATTTAGAGGCTTGGTTTCCTGGTTCCCAGGCTTTTAGAGAGCTTGTGTCATGCTCAAACTGTACAGACTAT
C/T AGGCTCGTCGCTTGCGGATTCGATACGGGCAAACTAAGAAAATGATGGACAAGGTACTACTCTTTTCTGAGCAAGGAAGTTCTGGATATTATATGTTTACAGTTTCAGGTTGGTTTAACTATTGTGTCTGCTTTTATTACAGGCTGAGTTTGTGCACATGCTCAATGCCACCATGTGTGCGACCACTCGTGTCATCTGTGCCATCCTGGAGAACTTCCAAACAGAGGAAGGCATCATTGTTCCAGAACCCCTCAAGGCATTCATGCCTCCAGGTGAGTGTTATTATTAAGCTTGATTTGTTTAGCTAAAGTTTGATACTTAATAGATTTTCTTTAGATGACTTACTTCTAATGCTGATTCTTCTGAATGACGTTAAGAACTGATTCAGGTCATTAGTTTGGGAATCTGACATCAGTTGTTGCGCTCAGTCTTTGATACACTACACAGAACTGAGTCTGTTCTTTAAGAGTTTGACCACATTGGTTGAACTTTGATTTTGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sars1ko095/ko095 | Homozygous | ♀+/- ♂+/- | Fig. S1 from Fukui et al., 2009 | ||
| sars1ko095/ko095; y1Tg | Complex | 2 figures from Fukui et al., 2009 | Fig. 1 from Fukui et al., 2009 | ||
| sars1ko095/+; y1Tg | Complex | ||||
| sars1ko095/ko095; y1Tg + MO1-flt4 | Complex | 2 figures from Fukui et al., 2009 | Fig. 5 from Fukui et al., 2009 | ||
| sars1ko095/ko095; y1Tg + MO4-vegfaa | Complex | Fig. 5 from Fukui et al., 2009 | Fig. 5 from Fukui et al., 2009 | ||
| sars1ko095/ko095; y1Tg + MO1-vegfc | Complex | Fig. 5 from Fukui et al., 2009 | Fig. 5 from Fukui et al., 2009 | ||
| sars1ko095/ko095; y1Tg + MO1-kdr + MO3-kdrl | Complex | Fig. 5 from Fukui et al., 2009 | Fig. 5 from Fukui et al., 2009 |
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Supplemental Information
- Genotyping protocol
- None
- Lin, C.Y., Lee, H.C., Fu, C.Y., Ding, Y.Y., Chen, J.S., Lee, M.H., Huang, W.J., and Tsai, H.J. (2013) miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos. Nature communications. 4:2829
- Xu, X., Yi Shi, Y., Zhang, H.-M., Swindell, E.C., Marshall, A.G., Guo, M., Kishi, S., Yang, X.-L. (2012) Unique domain appended to vertebrate tRNA synthetase is essential for vascular development. Nature communications. 3:681
- Fukui, H., Hanaoka, R., and Kawahara, A. (2009) Noncanonical Activity of Seryl-tRNA Synthetase Is Involved in Vascular Development. Circulation research. 104(11):1253-1259
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