Genomic Feature
hu1999
- ID
- ZDB-ALT-090610-6
- Name
- hu1999
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Hubrecht Institute
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 25: 9007943 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
GATCTGGTCCCGCAGTTCCTGAGAAGGCAGTAAGGTTTTCCTTCACAATTATGTCCATCTCTATTCGACTTGAAGGGGAGGACGATGGCATCACCATCTTCCAGGAACAAAAGCCCAACTCTGAACTCTCCTGTAGACCTCTGTGTCTCATGTTTGTGGACGAGTCTGACCATGAGACCCTGACAGCCATCTTGGGACCTGTGGTAGCAGAACGGAAAGCCATGATGGAAAGTCGGCTCATCATTTCTGTTGGTGGTCTGCTACGCTCTTTTAGGTTCTTCTTCCGGGGCACAGGCTATGATGAGAAGATGGTCCGTGAAATGGAAGGCCTGGAAGCATCGGGCTCTACTTATATATGCACACTTTGTGACTCAACACGTGCTGAAGCCTCTCAAAACATGGTGCTGCATTCCATCACACGCAGCCATGATGAAAATCTCGAGCGCTATGAGATCTGGAGGAAAAATCCCTTCTCAGAGTCAGCAGACGAACTGCGTGAC
C/T GAGTCAAAGGTGTTTCTGCTAAGCCTTTCATGGAAACCCAGCCTACTCTGGATGCACTGCACTGTGATATTGGCAATGCGACTGAATTCTACAAAATCTTTCAGGATGAGATTGGAGAAGTCTACCAGAAGCCCAATCCGAGTCGAGAGGAGCGCCGCCGTTGGCGGTCAACCCTGGACAAGCAACTAAGAAAGAAAATGAAACTCAAGCCTGTGATGAGGATGAATGGAAACTATGCTCGTCGGCTGATGACACGTGAAGCGGTGGAGGCTGTTTGTGAGCTGGTTCCTTCTGCAGAACGACGTGAGGCTCTATTGAAACTGATGGACCTCTACTTGCAGATGAAGCCTGTATGGCGGTCAACTTGTCCCTCCAGAGACTGCCCTGACCAACTCTGTCAATACAGCTACAACTCTCAGCAATTTGCTGACCTTCTATCCTCCATGTTTAAGTATCGATATGATGGAAAAATCACCAACTACCTCCACAAGACCTTGGCC - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
rag1hu1999/hu1999 | Homozygous | ♀+/- ♂+/- | 4 figures from 4 publications | ||
rag1hu1999/hu1999 | Homozygous | Unknown | Fig. 3 from Parikka et al., 2012 | ||
rag1hu1999 | Unknown | Unknown | |||
rag1hu1999/hu1999; foxp3aum252/um252 | Complex | 2 figures from Kasheta et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Harjula, S.E., Saralahti, A.K., Ojanen, M.J.T., Rantapero, T., Uusi-Mäkelä, M.I.E., Nykter, M., Lohi, O., Parikka, M., Rämet, M. (2019) Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Developmental and comparative immunology. 103:103523
- Hernández, P.P., Strzelecka, P.M., Athanasiadis, E.I., Hall, D., Robalo, A.F., Collins, C.M., Boudinot, P., Levraud, J.P., Cvejic, A. (2018) Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 3(29):
- Luukinen, H., Hammarén, M.M., Vanha-Aho, L.M., Parikka, M. (2018) Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish. Journal of visualized experiments : JoVE. (140):
- Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
- Luukinen, H., Hammarén, M.M., Vanha-Aho, L.M., Svorjova, A., Kantanen, L., Järvinen, S., Luukinen, B.V., Dufour, E., Rämet, M., Hytönen, V.P., Parikka, M. (2017) Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model.. Disease models & mechanisms. 11(1)
- Hammarén, M.M., Oksanen, K.E., Nisula, H.M., Luukinen, B.V., Pesu, M., Rämet, M., Parikka, M. (2014) Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish. PLoS pathogens. 10:e1004190
- Saralahti, A., Piippo, H., Parikka, M., Henriques-Normark, B., Rämet, M., and Rounioja, S. (2014) Adult zebrafish model for pneumococcal pathogenesis. Developmental and comparative immunology. 42(2):345-53
- Oksanen, K.E., Halfpenny, N.J., Sherwood, E., Harjula, S.K., Hammarén, M.M., Ahava, M.J., Pajula, E.T., Lahtinen, M.J., Parikka, M., and Rämet, M. (2013) An adult zebrafish model for preclinical tuberculosis vaccine development. Vaccine. 31(45):5202-9
- Parikka, M., Hammarén, M.M., Harjula, S.K., Halfpenny, N.J., Oksanen, K.E., Lahtinen, M.J., Pajula, E.T., Iivanainen, A., Pesu, M., and Rämet, M. (2012) Mycobacterium marinum Causes a Latent Infection that Can Be Reactivated by Gamma Irradiation in Adult Zebrafish. PLoS pathogens. 8(9):e1002944
- Weerdenburg, E.M., Abdallah, A.M., Mitra, S., de Punder, K., van der Wel, N.N., Bird, S., Appelmelk, B.J., Bitter, W., van der Sar, A.M. (2012) ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cellular Microbiology. 14(5):728-739
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