Genomic Feature
w40
- ID
- ZDB-ALT-080903-9
- Name
- w40
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- David Raible Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 8830339 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Cys>Tyr (1)
- Flanking Sequence
-
AATTTTAATAAGTAAATTCTAATAGCTGATTTTTTTTAATCTTTGCCATGATGACAGTACATGATATTTTGCTTGATATTTATTTAGGATACTTTTATTCACCTTAAAGTGCAATTCAAATGCGAAACTGGATCGCTTTTCGATAAACAATTGAAAAAATATTGCTTAATATGGCTAATAATGCTGACCTAAAATGGCTTAAAAAAATTAAAACTTTTCCAAATTATCTCCTCCAGCTCTCCTGCATTTCTAATCGTAATAAATATTCTATTATTTTTAAGAAAATAAACCAAATTAATATGATGATGAGGATGATGTTGATGATAATAATAATAATAATAATAATAATAATAATAATAATAATAACAACAACAAATGTCTTCGAAGCCAGCCTCACCTGGAAAAATATAGCCTTCCCATCTACTCTCCAAAAGTTCGTAACAGGATAACCACTGTGACCTCGGCACGGAATCAATTCAAGAGCTGAGTTACAGTTCGGA
C/T AAAGCTTTTCTGCAAAGACAAGACATACAGTATTAAGTTAAGCTACATTACATTTCAGTTAAGCTTTTTATCATGCATGCATACATACATATGTAAAATTGCTGTTTTGCGGAAAATGTCATGTCCATCAAAATGATTAACAAGTCATAAGTGTTCCTCGGCTGAGTCATGAATGAGCGGATCAAATTCAAAGAATGAACATTTGGTGACCTAATGTGGGTATGTAATTTGGCTAGAGTATATTAAATACTCTCGTGGTAAATTTCTAAGTTCTCTTAACTGACATTTCTGCGTAAAAGTCTGTTTCCAAAAAGAGTTAACATATTACAACCATTTATGAATTTCTGTGGTACGGCTGATAATTTTAAACTAAACTATTTGTGCCTAGCTTTTCCTCAGTAAAAAAAAAAATGCACAAAACGCGAAGTGATTTGAAGTGACAGTGATCTGAATTACTGTTGTGTTAAACAGAAACTCAAAATTGCTAAAGCCTTCAAGAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| gcm2w40/w40 (AB) | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | ||
| gcm2w40/w40; s356tTg | Complex | 2 figures from Stawicki et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Stawicki, T.M., Owens, K.N., Linbo, T., Reinhart, K.E., Rubel, E.W., Raible, D.W. (2014) The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function. Disease models & mechanisms. 7:847-856
- Owens, K.N., Santos, F., Roberts, B., Linbo, T., Coffin, A.B., Knisely, A.J., Simon, J.A., Rubel, E.W., and Raible, D.W. (2008) Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. PLoS Genetics. 4(2):e1000020
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