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Gene

gcm2

ID
ZDB-GENE-050127-1
Name
glial cells missing transcription factor 2
Symbol
gcm2 Nomenclature History
Previous Names
  • Gcm-2 (1)
  • gcmb (1)
  • mero
  • merovingian
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within animal organ development; epidermal cell fate specification; and metal ion homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; head; macrophage; pharynx; and yolk. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gcm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hyperparathyroidism 4 617343
Hypoparathyroidism, familial isolated 2 618883
Associated With gcm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003902 Transcription regulator GCM domain
Family IPR039791 Chorion-specific transcription factor GCM
Homologous_superfamily IPR036115 GCM domain superfamily
Homologous_superfamily IPR043020 GCM, large domain
Homologous_superfamily IPR043021 GCM, small domain
Domain Details Per Protein
Protein Length Chorion-specific transcription factor GCM GCM domain superfamily GCM, large domain GCM, small domain Transcription regulator GCM domain
UniProtKB:Q68BU9 496
UniProtKB:Q5TLZ9 478
UniProtKB:Q2KT54 496
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations